MIR4518

Summary

MIR4518 (microRNA 4518, HGNC:41809) is a microRNA gene on chromosome 16p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616405 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41809
Approved symbol	MIR4518
Name	microRNA 4518
Location	16p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4518
Ensembl gene	ENSG00000266305
Ensembl biotype	miRNA
Entrez	100616405
RNAcentral	URS0000759B50 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580665

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580665 — 1 exons

Exon	Start	End
ENSE00002720353	30503919	30504001

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 85.31.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	85.31	gold quality
granulocyte	CL:0000094	82.17	gold quality
bone marrow	UBERON:0002371	79.57	gold quality
blood	UBERON:0000178	79.05	gold quality
anterior cingulate cortex	UBERON:0009835	72.92	gold quality
gastrocnemius	UBERON:0001388	72.46	gold quality
lymph node	UBERON:0000029	70.30	gold quality
endometrium	UBERON:0001295	69.91	gold quality
left adrenal gland	UBERON:0001234	69.82	gold quality
adrenal gland	UBERON:0002369	69.43	gold quality
tonsil	UBERON:0002372	69.33	gold quality
urinary bladder	UBERON:0001255	68.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.07	gold quality
body of pancreas	UBERON:0001150	67.95	gold quality
stomach	UBERON:0000945	67.65	gold quality
right lobe of liver	UBERON:0001114	66.87	gold quality
body of stomach	UBERON:0001161	66.60	gold quality
thoracic aorta	UBERON:0001515	66.09	gold quality
adult mammalian kidney	UBERON:0000082	66.00	gold quality
skin of abdomen	UBERON:0001416	65.82	gold quality
transverse colon	UBERON:0001157	65.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.27	gold quality
Ammon’s horn	UBERON:0001954	64.90	gold quality
right frontal lobe	UBERON:0002810	64.81	gold quality
zone of skin	UBERON:0000014	64.64	gold quality
intestine	UBERON:0000160	64.45	gold quality
adipose tissue	UBERON:0001013	64.44	gold quality
minor salivary gland	UBERON:0001830	64.41	gold quality
left coronary artery	UBERON:0001626	64.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.