MIR4519

Summary

MIR4519 (microRNA 4519, HGNC:41544) is a microRNA gene on chromosome 16p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616231 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41544
Approved symbol	MIR4519
Name	microRNA 4519
Location	16p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4519
Ensembl gene	ENSG00000265991
Ensembl biotype	miRNA
Entrez	100616231
RNAcentral	URS000075A0A9 — ncRNA, 58 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579767

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579767 — 1 exons

Exon	Start	End
ENSE00002732576	30875266	30875323

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 79.83.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1999 / max 22.1598, expressed in 634 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157095	1.1999	634

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.83	gold quality
placenta	UBERON:0001987	77.20	gold quality
urinary bladder	UBERON:0001255	73.65	gold quality
left adrenal gland	UBERON:0001234	71.49	gold quality
lung	UBERON:0002048	70.74	gold quality
tibial artery	UBERON:0007610	69.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.84	gold quality
gastrocnemius	UBERON:0001388	69.75	gold quality
popliteal artery	UBERON:0002250	69.75	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.61	gold quality
adult mammalian kidney	UBERON:0000082	69.47	gold quality
body of pancreas	UBERON:0001150	69.35	gold quality
left adrenal gland cortex	UBERON:0035825	68.88	gold quality
ascending aorta	UBERON:0001496	68.72	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.49	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.19	gold quality
heart left ventricle	UBERON:0002084	68.06	gold quality
right lobe of thyroid gland	UBERON:0001119	67.48	gold quality
saliva-secreting gland	UBERON:0001044	66.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.67	gold quality
Ammon’s horn	UBERON:0001954	66.53	gold quality
putamen	UBERON:0001874	66.39	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.05	gold quality
right frontal lobe	UBERON:0002810	65.94	gold quality
prostate gland	UBERON:0002367	65.84	gold quality
esophagus mucosa	UBERON:0002469	65.82	gold quality
skin of abdomen	UBERON:0001416	65.54	gold quality
omental fat pad	UBERON:0010414	65.43	gold quality
right atrium auricular region	UBERON:0006631	65.36	gold quality
anterior cingulate cortex	UBERON:0009835	64.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.