MIR451A

Summary

MIR451A (microRNA 451a, HGNC:32053) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574411 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32053
Approved symbol	MIR451A
Name	microRNA 451a
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-451
Ensembl gene	ENSG00000284565
Ensembl biotype	miRNA
OMIM	612071
Entrez	574411
RNAcentral	URS000068196F — miRNA, 72 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385059

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385059 — 1 exons

Exon	Start	End
ENSE00001500065	28861369	28861440

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• MicroRNAs miR-27a and miR-451 are involved in activating the expression of P-glycoprotein, the MDR1 gene product that confers cancer cell resistance to a broad range of chemotherapeutics. (PMID:18619946)
• DOX-resistant MCF-7 cells (MCF-7/DOX) exhibit a considerable dysregulation of the miRNAome profile and altered expression of miRNA processing enzymes Dicer and Argonaute 2. (PMID:18645025)
• overexpression of miR-451 down-regulated mRNA and protein levels of macrophage migration inhibitory factor (MIF) and decreased expression of reporter genes with MIF target sequences. (PMID:19318487)
• miR-451 showed dysregulation in myocardial infarction or fetal hearts when compared to healthy adults. (PMID:20075508)
• miR-451 is involved in the regulation of erythroid differentiation and functions as an enhancer of differentiation. (PMID:20218812)
• miR-451 is a regulator of the LKB1/AMPK pathway, and this may represent a fundamental mechanism that contributes to glioma cell adaptation in response to altered energy availability. (PMID:20227367)
• Data suggest that early erythroid progenitors in beta-thalassemia have a dysregulated miRNA-451 expression program. (PMID:20461517)
• Dicer knockout cells can generate mature miR-451 but not other miRNAs, whereas Ago2 knockout cells reconstituted with wild-type Ago2, but not Slicer-deficient Ago2, can process miR-451. (PMID:20699384)
• these studies reveal miR-451 impacts glioblastoma cell proliferation, invasion and apoptosis (PMID:20816946)
• Data suggest that targeting with the miR-451/RAB14 interaction might serve as a novel therapeutic application to treat NSCLC patients. (PMID:21358675)
• miR-451 and miR-709 function as potent suppressors of oncogenesis in NOTCH1-induced mouse T cell acute lymphoblastic leukemia (T-ALL), and miR-451 influences MYC expression in human T-ALL bearing NOTCH1 mutations. (PMID:21464222)
• MicroRNA-451 downregulation is associated with chronic myeloid leukemia. (PMID:21511335)
• berrantly expressed miRNA-451 may be associated with the development of non-small cell lung cancer (PMID:21875770)
• Data suggest that miR-451 is a novel candidate to circumvent recurrence and drug resistance in colorectal cancer and could be used as a marker to predict response to irinotecan in patients with colon carcinoma. (PMID:21948564)
• Results identifyed three miRs, miR-451, miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer, with miR-451 having the strongest prognostic impact. (PMID:22046085)
• Authors conclude that miR-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K/AKT pathway indirectly. (PMID:22179124)
• Levels of miR-378 were increased (p = 0.0003, AUC = 0.71), miR-451 levels were decreased (p < 0.0001, AUC = 0.77) in serum of renal cell carcinoma patients. (PMID:22440013)
• These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation (PMID:23146892)
• The sHLA-G triggered a modulation of mir-451 expression that may in turn modulate downstream gene expression, thus affecting CD4(+) T-cell function. (PMID:23220581)
• mathematical computer model of regulation of microRNA-451, LKB1 and AMPK in glioblastoma (PMID:23367447)
• Investigated miRNA deregulation in papillary thyroid carcinoma, particularly with lymph node (LN) metastasis. Expression of either miR-2861 or miR-451 in the LN group was significantly greater than that in the NLN group. (PMID:23609190)
• Loss of miR-451 expression is associated with hepatocellular carcinoma. (PMID:23740840)
• Decrease in the expression of miR-451 was associated with colorectal carcinoma. (PMID:23886157)
• over-expressed microRNA-451 in colon cancer cells might inhibit AMPK to activate mTORC1, which mediates FSCN1 expression and cancer cell progression. (PMID:23899558)
• MIF is a direct target of miR-451, and MIF regulates NPC cell growth and invasion. (PMID:24138931)
• Poly(A)-specific ribonuclease (PARN) is the enzyme responsible for the 3’-5’ exonucleolytic trimming of Ago2-cleaved pre-miR-451. (PMID:24209750)
• miR451 has a tumor-suppressing effect in human osteosarcoma. (PMID:24218283)
• data indicate that miR-145 and miR-451 act as tumor suppressors in adipose tissue (PMID:24375455)
• Data showed that serum levels of miR-22, miR-375 and miR-451 were increased in patients with Hashimoto’s thyroiditis . (PMID:24533739)
• MicroRNA-451 expression in neutrophils isolated from patients with rheumatoid arthritis was lower than that in healthy controls. (PMID:24574214)
• these results reveal a prominent role of miR-451 as a tumor suppressor regulating hepatoma cell growth and invasion (PMID:24841638)
• Loss of tumour suppressive miR-451a enhanced cancer cell migration and invasion in HSCC through direct regulation of ESDN. (PMID:24918822)
• Study identified a potential target of miR-451, ATF2, and revealed a novel role of miR-451 in the inhibition of the migratory ability of hepatoma cell lines. (PMID:24968707)
• Hsa-mir-93, hsa-mir-17, hsa-mir-22*, hsa-mir-126*, hsa-mir-142-3p, hsa-mir-144*, hsa-mir-486-5p, hsa-mir-451, and hsa-mir-92a were up-regulated and hsa-mir-30a, hsa-mir-382, and hsa-mir-136 were down-regulated in bromocriptine-resistant prolactinomas (PMID:25064468)
• miR-451 related to PSMB8/NOS2 inflammatory factors may suppress the development and migration of lung cancer. (PMID:25150396)
• PAX4-miR-144/451-ADAMs axis regulates human epithelial cancer metastasis (PMID:25151965)
• the miR-451/RAB14 interaction plays an important role in the enhancement of radiosensitivity in NPC cells. (PMID:25201065)
• The down-regulation of miR-451 may contribute to the development of hypertrophic cardiomyopathy and may be a potential therapeutic target for this disease. (PMID:25209900)
• This newly identified miR-451/c- Myc/ERK/GSK-3b axis provides novel insight into the molecular mechanisms which regulate metastases progression, and further provides novel therapeutic strategies for chemoresistant LAD patients. (PMID:25310895)
• RAB14 is a direct target of MIR451. As MIR451 expression increased during human erythropoiesis, RAB14 protein expression decreased. (PMID:25312678)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-451a	ENSDARG00000082898
rattus_norvegicus	Mir451a	ENSRNOG00000036258

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.