MIR452

Summary

MIR452 (microRNA 452, HGNC:32054) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574412 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32054
Approved symbol	MIR452
Name	microRNA 452
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-452
Ensembl gene	ENSG00000283751
Ensembl biotype	miRNA
Entrez	574412
RNAcentral	URS00006BFE9D — miRNA, 85 nt, 24 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385020

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385020 — 1 exons

Exon	Start	End
ENSE00001500027	151959628	151959712

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 63.84.

Top tissues by expression

2 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right atrium auricular region	UBERON:0006631	63.84	gold quality
left adrenal gland cortex	UBERON:0035825	48.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 39)

• Overexpression of miR-452 and miR-452* were associated with node positive urothelial carcinomas. (PMID:19127597)
• Downregulation of miR-452 plays an important role in promoting the stem-like traits and tumorigenesis of gliomas and may represent a novel prognostic biomarker and therapeutic target for the disease. (PMID:23695168)
• MiR-452 directly targets the 3’-untranslated region of cyclin-dependent kinase inhibitor 1B (CDKN1B). (PMID:24381057)
• miR-452 expression correlated with intracellular T3 concentrations in renal tumors. (PMID:24440748)
• Dysregulation of miRNA-452 involved in the DOC resistance formation of breast cancer cells may be, in part, via targeting APC4. (PMID:24648265)
• Data indicate that GABA(A) receptor subunit epsilon (GABRE) approximately miR-452 approximately miR-224 locus is downregulated and hypermethylated in prostate cancer and is a promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. (PMID:24737792)
• Dysregulation of miR-452 played an important role in the acquired adriamycin-resistance of breast cancer. (PMID:25040964)
• Data identify the metastasis suppressor TXNIP as new target of miR-224/miR-452 that induces feedback inhibition of E2F1 and show that miR-224/452-mediated downregulation of TXNIP is essential for E2F1-induced EMT and invasion (PMID:25341426)
• We have testified that 5 miRNA is related to MDR before, in this study, the expression of miR-34a, miR-222, miR-452 and miR-29a can lead to changes of the characteristics of chemo-resistant MCF-7/Adr and MCF-7/Doc (PMID:25562151)
• MiR-452 modulated BMI1 expression. (PMID:26316085)
• miR-452 treatment could be a novel target or strategy for NSCLC treatment (PMID:26718215)
• These data suggested that miR-452 promoted stem-like traits of hepatocellular carcinoma (PMID:27058905)
• Results show that miR-452 expression is downregulated in prostate cancer (PCa) clinical specimens, and functions as a tumor suppressor in PCa cells. Expression of miR-452 predicted a short duration of progression to castration-resistant PCa.This report demonstrates also, that miR-452 directly targets WWP1. (PMID:27070713)
• low expression of miR-452-5p tends to play an essential role in lung adenocarcinoma. Bioinformatics analysis might be beneficial to reveal the potential mechanism of miR-452-5p in lung adenocarcinoma. (PMID:28488527)
• In addition to its angiogenic action, VEGFA upregulates Sox2 to drive stem cell expansion, together with miR-452 loss and Slug upregulation, providing a novel mechanism whereby cancer stem cells acquire metastatic potential. (PMID:28504716)
• miR-452 is epigenetically silenced and targets BMI1 to exert a growth suppressive activity in T-cell acute lymphoblastic leukemia. (PMID:29326345)
• Down-regulated miR-452-5p might play an essential role in the tumorigenesis of prostate cancer. (PMID:29559248)
• The luciferase reporter system studies affirmed the direct regulation of miR-452 on the 3’-UTR of the GSK3b, which activate the Wnt/b-catenin signaling. The ectopic upregulation of miR-452 significantly inhibited the expression of GSK3b and enhanced colorectal cancer (CRC) proliferation and invasion in vitro and in vivo. (PMID:30253791)
• Study demonstrates for the first time that miR-139 and miR-452 negatively regulate RGS13 expression which is known to be involved in germinal centers regulation. (PMID:30308012)
• Our study presented a road map for targeting this newly identified miR-452-5p and its SMAD4/SMAD7 signals pathway, which imparted a new potential therapeutic strategy for mRCC treatment. (PMID:30419914)
• These results indicate that IH stress down-regulates the miR-452 in adipocytes, resulting in increased levels of RETN, TNFalpha, and CCL2 mRNAs, leading to insulin resistance in SAS patients. (PMID:31013606)
• miR-452 promotes the development of gastric cancer via targeting EPB41L3. (PMID:31734055)
• Circular RNA-ABCB10 suppresses hepatocellular carcinoma progression through upregulating NRP1/ABL2 via sponging miR-340-5p/miR-452-5p. (PMID:32196586)
• Long Noncoding RNA SOX2-OT Knockdown Inhibits Proliferation and Metastasis of Prostate Cancer Cells Through Modulating the miR-452-5p/HMGB3 Axis and Inactivating Wnt/beta-Catenin Pathway. (PMID:32407168)
• CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis. (PMID:32722658)
• Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis. (PMID:33204323)
• MicroRNA 452 regulates ASB8, NOL8, and CDR2 expression in colorectal cancer cells. (PMID:33398662)
• MiR-452-5p promotes colorectal cancer progression by regulating an ERK/MAPK positive feedback loop. (PMID:33658394)
• MicroRNAs miR-18a and miR-452 regulate the replication of enterovirus 71 by targeting the gene encoding VP3. (PMID:34002325)
• [Targeted binding of rs1053005 locus of STAT3 with miR-452-3p and the association between STAT3 gene polymorphism and noise-induced hearing loss]. (PMID:34218555)
• MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer. (PMID:34283251)
• MicroRNA 452 regulates GTF2E1 expression in colorectal cancer cells. (PMID:34553694)
• CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia. (PMID:35120971)
• Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity. (PMID:35401881)
• LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network. (PMID:35988287)
• MicroRNA-452: a double-edged sword in multiple human cancers. (PMID:36622551)
• NF-kappaB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells. (PMID:37175530)
• MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis. (PMID:37523129)
• MiRNAs from the Dlk1-Dio3 locus and miR-224/452 cluster contribute to glioblastoma tumor heterogeneity. (PMID:38609422)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.