MIR4520-1

Summary

MIR4520-1 (microRNA 4520-1, HGNC:41775) is a microRNA gene on chromosome 17p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616401 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41775
Approved symbol	MIR4520-1
Name	microRNA 4520-1
Location	17p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4520a
Ensembl gene	ENSG00000264468
Ensembl biotype	miRNA
Entrez	100616401
RNAcentral	URS000075F124 — miRNA, 70 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582609

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582609 — 1 exons

Exon	Start	End
ENSE00002716676	6655440	6655509

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 90.25.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	90.25	gold quality
duodenum	UBERON:0002114	84.81	gold quality
sural nerve	UBERON:0015488	83.75	gold quality
lower esophagus mucosa	UBERON:0035834	83.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.25	gold quality
monocyte	CL:0000576	78.88	gold quality
blood	UBERON:0000178	78.07	gold quality
lymph node	UBERON:0000029	77.67	gold quality
tonsil	UBERON:0002372	76.11	gold quality
skin of abdomen	UBERON:0001416	76.03	gold quality
esophagus mucosa	UBERON:0002469	75.56	gold quality
zone of skin	UBERON:0000014	75.49	gold quality
skin of leg	UBERON:0001511	74.85	gold quality
esophagus	UBERON:0001043	74.66	gold quality
pituitary gland	UBERON:0000007	74.29	gold quality
muscle of leg	UBERON:0001383	73.85	gold quality
islet of Langerhans	UBERON:0000006	73.43	gold quality
putamen	UBERON:0001874	73.26	gold quality
adenohypophysis	UBERON:0002196	73.21	gold quality
gastrocnemius	UBERON:0001388	72.57	gold quality
small intestine	UBERON:0002108	72.53	gold quality
right lobe of liver	UBERON:0001114	72.50	gold quality
endometrium	UBERON:0001295	72.38	gold quality
metanephros cortex	UBERON:0010533	72.08	gold quality
pancreas	UBERON:0001264	72.03	gold quality
caudate nucleus	UBERON:0001873	71.72	gold quality
liver	UBERON:0002107	71.71	gold quality
small intestine Peyer’s patch	UBERON:0003454	71.68	gold quality
prefrontal cortex	UBERON:0000451	71.32	gold quality
saliva-secreting gland	UBERON:0001044	71.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• RHEB, the main activator of mTOR signaling, is a valid target of miR-4520a with the relative expression levels of the latter being significantly deregulated in FMF patients and highly dependent on the presence of pyrin mutations. (PMID:27636101)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.