MIR4521

Summary

MIR4521 (microRNA 4521, HGNC:41813) is a microRNA gene on chromosome 17p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616406 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41813
Approved symbol	MIR4521
Name	microRNA 4521
Location	17p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4521
Ensembl gene	ENSG00000283160
Ensembl biotype	miRNA
Entrez	100616406
RNAcentral	URS000075D8EE — ncRNA, 60 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635897

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635897 — 1 exons

Exon	Start	End
ENSE00003800563	8186945	8187004

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 82.14.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	82.14	gold quality
blood	UBERON:0000178	80.49	gold quality
sural nerve	UBERON:0015488	79.62	gold quality
bone marrow	UBERON:0002371	78.20	gold quality
descending thoracic aorta	UBERON:0002345	76.72	gold quality
monocyte	CL:0000576	76.62	gold quality
muscle of leg	UBERON:0001383	75.36	gold quality
gastrocnemius	UBERON:0001388	74.78	gold quality
endometrium	UBERON:0001295	74.71	gold quality
calcaneal tendon	UBERON:0003701	74.22	gold quality
lymph node	UBERON:0000029	73.85	gold quality
liver	UBERON:0002107	73.08	gold quality
popliteal artery	UBERON:0002250	72.47	gold quality
tibial artery	UBERON:0007610	72.43	gold quality
islet of Langerhans	UBERON:0000006	72.00	gold quality
rectum	UBERON:0001052	71.82	gold quality
right lobe of liver	UBERON:0001114	71.72	gold quality
body of pancreas	UBERON:0001150	71.67	gold quality
stomach	UBERON:0000945	71.51	gold quality
heart	UBERON:0000948	71.47	gold quality
right atrium auricular region	UBERON:0006631	70.53	gold quality
heart left ventricle	UBERON:0002084	70.15	gold quality
amygdala	UBERON:0001876	69.65	gold quality
body of stomach	UBERON:0001161	69.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.45	gold quality
left coronary artery	UBERON:0001626	69.23	gold quality
left adrenal gland cortex	UBERON:0035825	69.13	gold quality
thoracic aorta	UBERON:0001515	68.95	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.86	gold quality
substantia nigra	UBERON:0002038	68.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.85

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• identified differential expression of hsa-miR-4521 in brain tissue and serum of refractory epilepsy patients and suggested that serum hsa-miR-4521 may represent a potential diagnostic biomarker for FCD with refractory epilepsy. (PMID:26645999)
• High impact of miRNA-4521 on FOXM1 expression in medulloblastoma. (PMID:31541075)
• Hypoxia downregulated miR-4521 suppresses gastric carcinoma progression through regulation of IGF2 and FOXM1. (PMID:33407516)
• A novel prognostic mRNA/miRNA signature for esophageal cancer and its immune landscape in cancer progression. (PMID:33463006)
• Comparative expression analysis of tRF-3001a and tRF-1003 with corresponding miRNAs (miR-1260a and miR-4521) and their network analysis with breast cancer biomarkers. (PMID:34661810)
• MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A. (PMID:35127170)
• miR-4521-A novel biomarker for human lentigos. (PMID:38874433)
• Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction. (PMID:39235443)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.