MIR4522

Summary

MIR4522 (microRNA 4522, HGNC:41668) is a microRNA gene on chromosome 17q11.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616277 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41668
Approved symbol	MIR4522
Name	microRNA 4522
Location	17q11.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4522
Ensembl gene	ENSG00000263583
Ensembl biotype	miRNA
Entrez	100616277
RNAcentral	URS0000114517 — ncRNA, 87 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584932

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584932 — 1 exons

Exon	Start	End
ENSE00003642650	27293910	27293996

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 85.93.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.93	gold quality
adrenal tissue	UBERON:0018303	81.26	gold quality
vermiform appendix	UBERON:0001154	79.30	gold quality
corpus callosum	UBERON:0002336	76.44	gold quality
islet of Langerhans	UBERON:0000006	74.64	gold quality
blood	UBERON:0000178	73.37	gold quality
heart left ventricle	UBERON:0002084	73.07	gold quality
monocyte	CL:0000576	72.76	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.56	gold quality
body of pancreas	UBERON:0001150	70.38	gold quality
stomach	UBERON:0000945	70.27	gold quality
body of stomach	UBERON:0001161	70.20	gold quality
adrenal gland	UBERON:0002369	69.98	gold quality
putamen	UBERON:0001874	68.96	gold quality
heart	UBERON:0000948	68.83	gold quality
right atrium auricular region	UBERON:0006631	68.46	gold quality
left adrenal gland	UBERON:0001234	67.62	gold quality
gastrocnemius	UBERON:0001388	67.21	gold quality
tibial artery	UBERON:0007610	67.19	gold quality
left adrenal gland cortex	UBERON:0035825	67.12	gold quality
left ovary	UBERON:0002119	66.95	gold quality
ascending aorta	UBERON:0001496	66.61	gold quality
left coronary artery	UBERON:0001626	66.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.60	gold quality
hypothalamus	UBERON:0001898	66.34	gold quality
thoracic aorta	UBERON:0001515	66.19	gold quality
Ammon’s horn	UBERON:0001954	65.83	gold quality
omental fat pad	UBERON:0010414	65.65	gold quality
nucleus accumbens	UBERON:0001882	65.12	gold quality
skin of abdomen	UBERON:0001416	64.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.22

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.