MIR4524B

Summary

MIR4524B (microRNA 4524b, HGNC:43520) is a microRNA gene on chromosome 17q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847008 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43520
Approved symbol	MIR4524B
Name	microRNA 4524b
Location	17q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4524b
Ensembl gene	ENSG00000265331
Ensembl biotype	miRNA
Entrez	100847008
RNAcentral	URS000075BC45 — miRNA, 115 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581569

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581569 — 1 exons

Exon	Start	End
ENSE00002686433	69099542	69099656

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 89.42.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of stomach	UBERON:0001199	89.42	gold quality
sural nerve	UBERON:0015488	85.23	gold quality
subcutaneous adipose tissue	UBERON:0002190	84.37	gold quality
right lung	UBERON:0002167	83.59	gold quality
tibial nerve	UBERON:0001323	83.57	gold quality
liver	UBERON:0002107	82.02	gold quality
adipose tissue	UBERON:0001013	80.79	gold quality
adult mammalian kidney	UBERON:0000082	80.67	gold quality
calcaneal tendon	UBERON:0003701	80.28	gold quality
left ovary	UBERON:0002119	80.22	gold quality
ovary	UBERON:0000992	78.71	gold quality
right atrium auricular region	UBERON:0006631	77.12	gold quality
right ovary	UBERON:0002118	76.80	gold quality
thoracic mammary gland	UBERON:0005200	76.67	gold quality
muscle of leg	UBERON:0001383	76.57	gold quality
right lobe of liver	UBERON:0001114	76.54	gold quality
gastrocnemius	UBERON:0001388	76.31	gold quality
urinary bladder	UBERON:0001255	75.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.71	gold quality
skin of leg	UBERON:0001511	75.67	gold quality
omental fat pad	UBERON:0010414	75.58	gold quality
body of uterus	UBERON:0009853	75.27	gold quality
heart	UBERON:0000948	75.11	gold quality
saliva-secreting gland	UBERON:0001044	74.81	gold quality
monocyte	CL:0000576	74.73	gold quality
zone of skin	UBERON:0000014	74.68	gold quality
minor salivary gland	UBERON:0001830	74.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.25	gold quality
lung	UBERON:0002048	74.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	74.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• found that miR-4524b-5p could regulate the migration and invasion of cervical cancer by targeting WTX and that WTX could regulate the expression of beta-catenin (PMID:30939162)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.