MIR4525

Summary

MIR4525 (microRNA 4525, HGNC:41903) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616196 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41903
Approved symbol	MIR4525
Name	microRNA 4525
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4525
Ensembl gene	ENSG00000266107
Ensembl biotype	miRNA
Entrez	100616196
RNAcentral	URS000075E1F1 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580000

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580000 — 1 exons

Exon	Start	End
ENSE00002684704	82668233	82668307

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 84.81.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	84.81	gold quality
prefrontal cortex	UBERON:0000451	82.19	gold quality
blood	UBERON:0000178	77.37	gold quality
adrenal tissue	UBERON:0018303	75.86	gold quality
monocyte	CL:0000576	74.85	gold quality
sural nerve	UBERON:0015488	73.31	gold quality
muscle of leg	UBERON:0001383	72.80	gold quality
gastrocnemius	UBERON:0001388	72.41	gold quality
islet of Langerhans	UBERON:0000006	72.07	gold quality
endometrium	UBERON:0001295	71.16	gold quality
adult mammalian kidney	UBERON:0000082	70.66	gold quality
nucleus accumbens	UBERON:0001882	70.18	gold quality
heart left ventricle	UBERON:0002084	69.76	gold quality
right uterine tube	UBERON:0001302	69.64	gold quality
fallopian tube	UBERON:0003889	69.42	gold quality
right lobe of liver	UBERON:0001114	69.32	gold quality
left uterine tube	UBERON:0001303	69.26	gold quality
putamen	UBERON:0001874	69.17	gold quality
caudate nucleus	UBERON:0001873	69.12	gold quality
thoracic aorta	UBERON:0001515	69.11	gold quality
right atrium auricular region	UBERON:0006631	68.66	gold quality
Ammon’s horn	UBERON:0001954	68.63	gold quality
stomach	UBERON:0000945	68.40	gold quality
body of stomach	UBERON:0001161	68.08	gold quality
ascending aorta	UBERON:0001496	68.01	gold quality
fundus of stomach	UBERON:0001160	67.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.74	gold quality
transverse colon	UBERON:0001157	67.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.30	gold quality
right frontal lobe	UBERON:0002810	67.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Profiling of Serum Extracellular Vesicles Reveals miRNA-4525 as a Potential Biomarker for Advanced Renal Cell Carcinoma. (PMID:33893078)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.