MIR4526

Summary

MIR4526 (microRNA 4526, HGNC:41618) is a microRNA gene on chromosome 18p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616130 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41618
Approved symbol	MIR4526
Name	microRNA 4526
Location	18p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4526
Ensembl gene	ENSG00000263527
Ensembl biotype	miRNA
Entrez	100616130
RNAcentral	URS000075F0CA — miRNA, 87 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583168

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583168 — 1 exons

Exon	Start	End
ENSE00002729234	13611114	13611200

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 85.89.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	85.89	gold quality
kidney	UBERON:0002113	80.32	gold quality
bone marrow	UBERON:0002371	79.04	gold quality
blood	UBERON:0000178	77.16	gold quality
adrenal tissue	UBERON:0018303	77.00	gold quality
liver	UBERON:0002107	76.83	gold quality
monocyte	CL:0000576	76.14	gold quality
muscle of leg	UBERON:0001383	74.70	gold quality
calcaneal tendon	UBERON:0003701	73.67	gold quality
gall bladder	UBERON:0002110	72.75	gold quality
gastrocnemius	UBERON:0001388	72.64	gold quality
right lobe of liver	UBERON:0001114	71.41	gold quality
body of stomach	UBERON:0001161	71.40	gold quality
right testis	UBERON:0004534	70.30	gold quality
heart left ventricle	UBERON:0002084	69.04	gold quality
stomach	UBERON:0000945	68.88	gold quality
myometrium	UBERON:0001296	68.69	gold quality
granulocyte	CL:0000094	68.63	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.57	gold quality
heart	UBERON:0000948	68.31	gold quality
substantia nigra	UBERON:0002038	68.31	gold quality
smooth muscle tissue	UBERON:0001135	67.93	gold quality
testis	UBERON:0000473	67.66	gold quality
endometrium	UBERON:0001295	67.64	gold quality
tibial artery	UBERON:0007610	67.58	gold quality
popliteal artery	UBERON:0002250	67.56	gold quality
Ammon’s horn	UBERON:0001954	67.54	gold quality
body of uterus	UBERON:0009853	67.54	gold quality
lower esophagus	UBERON:0013473	67.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.