MIR4527

Summary

MIR4527 (microRNA 4527, HGNC:41633) is a microRNA gene on chromosome 18q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616264 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41633
Approved symbol	MIR4527
Name	microRNA 4527
Location	18q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4527
Ensembl gene	ENSG00000266582
Ensembl biotype	miRNA
Entrez	100616264
RNAcentral	URS000075C914 — ncRNA, 70 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584505

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584505 — 1 exons

Exon	Start	End
ENSE00002704547	47380496	47380565

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 64.37.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	64.37	gold quality
esophagus mucosa	UBERON:0002469	62.39	gold quality
thyroid gland	UBERON:0002046	59.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	56.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.