MIR4528

Summary

MIR4528 (microRNA 4528, HGNC:41547) is a microRNA gene on chromosome 18q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616232 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41547
Approved symbol	MIR4528
Name	microRNA 4528
Location	18q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4528
Ensembl gene	ENSG00000263872
Ensembl biotype	miRNA
Entrez	100616232
RNAcentral	URS00007E4A4B — ncRNA, 90 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577763

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577763 — 1 exons

Exon	Start	End
ENSE00002695332	53237101	53237190

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 71.69.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	71.69	gold quality
stomach	UBERON:0000945	69.77	gold quality
nucleus accumbens	UBERON:0001882	64.64	gold quality
cerebellar hemisphere	UBERON:0002245	63.74	gold quality
pituitary gland	UBERON:0000007	62.31	gold quality
putamen	UBERON:0001874	60.42	gold quality
right frontal lobe	UBERON:0002810	53.24	gold quality
left testis	UBERON:0004533	36.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.