MIR4529

Summary

MIR4529 (microRNA 4529, HGNC:41703) is a microRNA gene on chromosome 18q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616290 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41703
Approved symbol	MIR4529
Name	microRNA 4529
Location	18q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4529
Ensembl gene	ENSG00000264571
Ensembl biotype	miRNA
Entrez	100616290
RNAcentral	URS000075CE31 — miRNA, 78 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578110

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578110 — 1 exons

Exon	Start	End
ENSE00002729524	55479221	55479298

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 81.32.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal gland	UBERON:0002369	81.32	gold quality
adrenal tissue	UBERON:0018303	80.19	gold quality
calcaneal tendon	UBERON:0003701	79.16	gold quality
nucleus accumbens	UBERON:0001882	77.46	gold quality
monocyte	CL:0000576	74.82	gold quality
stomach	UBERON:0000945	73.58	gold quality
gastrocnemius	UBERON:0001388	72.31	gold quality
lung	UBERON:0002048	70.41	gold quality
esophagus mucosa	UBERON:0002469	66.68	gold quality
tibial artery	UBERON:0007610	66.17	gold quality
intestine	UBERON:0000160	66.09	gold quality
upper lobe of left lung	UBERON:0008952	64.86	gold quality
ascending aorta	UBERON:0001496	64.56	gold quality
heart left ventricle	UBERON:0002084	64.38	gold quality
transverse colon	UBERON:0001157	64.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.97	gold quality
skin of abdomen	UBERON:0001416	63.66	gold quality
putamen	UBERON:0001874	63.59	gold quality
amygdala	UBERON:0001876	63.44	gold quality
right ovary	UBERON:0002118	63.34	gold quality
prostate gland	UBERON:0002367	63.06	gold quality
thoracic mammary gland	UBERON:0005200	63.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.88	gold quality
vagina	UBERON:0000996	60.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.15	gold quality
left ovary	UBERON:0002119	58.90	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.85	gold quality
right hemisphere of cerebellum	UBERON:0014890	58.75	gold quality
cerebellar hemisphere	UBERON:0002245	58.29	gold quality
Brodmann (1909) area 9	UBERON:0013540	57.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-4529-3p Promotes the Progression of Retinoblastoma by Inhibiting RB1 Expression and Activating the ERK Signaling Pathway. (PMID:37041423)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.