MIR4530

Summary

MIR4530 (microRNA 4530, HGNC:41764) is a microRNA gene on chromosome 19q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616163 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41764
Approved symbol	MIR4530
Name	microRNA 4530
Location	19q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4530
Ensembl gene	ENSG00000266559
Ensembl biotype	miRNA
Entrez	100616163
RNAcentral	URS000075BB21 — miRNA, 56 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581459

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581459 — 1 exons

Exon	Start	End
ENSE00002710719	39409623	39409678

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 99.26.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5523 / max 100.3925, expressed in 207 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180881	0.5523	207

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.26	gold quality
skeletal muscle tissue	UBERON:0001134	87.51	gold quality
left uterine tube	UBERON:0001303	87.13	gold quality
granulocyte	CL:0000094	85.00	gold quality
monocyte	CL:0000576	83.95	gold quality
mucosa of stomach	UBERON:0001199	80.65	gold quality
blood	UBERON:0000178	79.02	gold quality
omental fat pad	UBERON:0010414	78.73	gold quality
bone marrow	UBERON:0002371	78.46	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.94	gold quality
fallopian tube	UBERON:0003889	77.81	gold quality
fundus of stomach	UBERON:0001160	77.66	gold quality
right coronary artery	UBERON:0001625	77.61	gold quality
ascending aorta	UBERON:0001496	77.32	gold quality
thoracic aorta	UBERON:0001515	77.03	gold quality
muscle of leg	UBERON:0001383	77.02	gold quality
body of stomach	UBERON:0001161	77.01	gold quality
stomach	UBERON:0000945	76.65	gold quality
gastrocnemius	UBERON:0001388	76.19	gold quality
descending thoracic aorta	UBERON:0002345	75.83	gold quality
right atrium auricular region	UBERON:0006631	75.57	gold quality
heart left ventricle	UBERON:0002084	75.56	gold quality
adipose tissue	UBERON:0001013	75.53	gold quality
heart	UBERON:0000948	75.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.28	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.87	gold quality
lower esophagus	UBERON:0013473	74.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	74.78	gold quality
smooth muscle tissue	UBERON:0001135	74.71	gold quality
esophagus	UBERON:0001043	74.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The results suggested that miRNA4530 suppresses cell proliferation and enhances apoptosis by targeting RASA1 via the ERK/MAPK and PI3K/AKT signaling pathways. (PMID:30864691)
• miR-4530 inhibits the malignant biological behaviors of human glioma cells by directly targeting RTEL1. (PMID:33200790)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.