MIR4531

Summary

MIR4531 (microRNA 4531, HGNC:41872) is a microRNA gene on chromosome 19q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616355 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41872
Approved symbol	MIR4531
Name	microRNA 4531
Location	19q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4531
Ensembl gene	ENSG00000283673
Ensembl biotype	miRNA
Entrez	100616355
RNAcentral	URS0000759ABE — miRNA, 47 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636960

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636960 — 1 exons

Exon	Start	End
ENSE00003799627	44653686	44653732

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 87.38.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	87.38	gold quality
adrenal tissue	UBERON:0018303	84.09	gold quality
anterior cingulate cortex	UBERON:0009835	81.45	gold quality
blood	UBERON:0000178	80.63	gold quality
gastrocnemius	UBERON:0001388	78.57	gold quality
monocyte	CL:0000576	77.61	gold quality
stomach	UBERON:0000945	76.98	gold quality
islet of Langerhans	UBERON:0000006	75.59	gold quality
placenta	UBERON:0001987	75.54	gold quality
liver	UBERON:0002107	75.50	gold quality
right lobe of liver	UBERON:0001114	73.84	gold quality
adrenal gland	UBERON:0002369	73.00	gold quality
tibial artery	UBERON:0007610	72.62	gold quality
adult mammalian kidney	UBERON:0000082	72.42	gold quality
heart	UBERON:0000948	72.37	gold quality
heart left ventricle	UBERON:0002084	72.23	gold quality
body of stomach	UBERON:0001161	72.20	gold quality
left adrenal gland cortex	UBERON:0035825	71.98	gold quality
body of pancreas	UBERON:0001150	71.43	gold quality
putamen	UBERON:0001874	71.35	gold quality
left ovary	UBERON:0002119	71.09	gold quality
omental fat pad	UBERON:0010414	70.93	gold quality
right atrium auricular region	UBERON:0006631	70.72	gold quality
transverse colon	UBERON:0001157	70.61	gold quality
thoracic aorta	UBERON:0001515	70.49	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.38	gold quality
colon	UBERON:0001155	70.31	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.27	gold quality
ascending aorta	UBERON:0001496	70.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.