MIR4533

Summary

MIR4533 (microRNA 4533, HGNC:41886) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616362 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41886
Approved symbol	MIR4533
Name	microRNA 4533
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4533
Ensembl gene	ENSG00000266140
Ensembl biotype	miRNA
Entrez	100616362
RNAcentral	URS000075E65F — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581943

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581943 — 1 exons

Exon	Start	End
ENSE00002734259	60478111	60478181

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 76.55.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.55	gold quality
adrenal tissue	UBERON:0018303	75.89	gold quality
left coronary artery	UBERON:0001626	73.24	gold quality
stomach	UBERON:0000945	72.71	gold quality
gastrocnemius	UBERON:0001388	72.60	gold quality
lung	UBERON:0002048	72.25	gold quality
amygdala	UBERON:0001876	71.96	gold quality
granulocyte	CL:0000094	71.95	gold quality
body of stomach	UBERON:0001161	70.12	gold quality
heart left ventricle	UBERON:0002084	69.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.67	gold quality
thoracic aorta	UBERON:0001515	68.39	gold quality
ascending aorta	UBERON:0001496	68.08	gold quality
liver	UBERON:0002107	67.90	gold quality
right atrium auricular region	UBERON:0006631	67.75	gold quality
body of pancreas	UBERON:0001150	67.36	gold quality
left adrenal gland cortex	UBERON:0035825	67.07	gold quality
endometrium	UBERON:0001295	67.06	gold quality
prostate gland	UBERON:0002367	67.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.85	gold quality
myometrium	UBERON:0001296	66.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.94	gold quality
adipose tissue	UBERON:0001013	65.89	gold quality
adult mammalian kidney	UBERON:0000082	65.79	gold quality
transverse colon	UBERON:0001157	65.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.58	gold quality
putamen	UBERON:0001874	65.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.08	gold quality
esophagus	UBERON:0001043	64.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.