MIR4534

Summary

MIR4534 (microRNA 4534, HGNC:41692) is a microRNA gene on chromosome 22q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616146 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41692
Approved symbol	MIR4534
Name	microRNA 4534
Location	22q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4534
Ensembl gene	ENSG00000284266
Ensembl biotype	miRNA
Entrez	100616146
RNAcentral	URS000075A377 — ncRNA, 60 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578108

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578108 — 1 exons

Exon	Start	End
ENSE00002685942	37988794	37988853

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 95.98.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.98	gold quality
skeletal muscle tissue	UBERON:0001134	90.11	gold quality
prefrontal cortex	UBERON:0000451	88.21	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.57	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.40	gold quality
Ammon’s horn	UBERON:0001954	81.68	gold quality
substantia nigra	UBERON:0002038	80.59	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.33	gold quality
putamen	UBERON:0001874	79.84	gold quality
amygdala	UBERON:0001876	79.43	gold quality
corpus callosum	UBERON:0002336	78.85	gold quality
tibial nerve	UBERON:0001323	78.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.42	gold quality
caudate nucleus	UBERON:0001873	78.11	gold quality
cerebral cortex	UBERON:0000956	77.97	gold quality
hypothalamus	UBERON:0001898	77.68	gold quality
brain	UBERON:0000955	76.66	gold quality
adrenal tissue	UBERON:0018303	76.65	gold quality
frontal cortex	UBERON:0001870	76.31	gold quality
nucleus accumbens	UBERON:0001882	76.28	gold quality
blood	UBERON:0000178	75.79	gold quality
right frontal lobe	UBERON:0002810	75.39	gold quality
muscle of leg	UBERON:0001383	75.33	gold quality
anterior cingulate cortex	UBERON:0009835	74.55	gold quality
heart left ventricle	UBERON:0002084	74.39	gold quality
gastrocnemius	UBERON:0001388	74.37	gold quality
cerebellar hemisphere	UBERON:0002245	73.80	gold quality
kidney	UBERON:0002113	72.12	gold quality
stomach	UBERON:0000945	71.77	gold quality
apex of heart	UBERON:0002098	71.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data show that miR-4534 exerts its oncogenic effects partly by downregulating the tumor suppressor PTEN gene. (PMID:27634912)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.