MIR4535

Summary

MIR4535 (microRNA 4535, HGNC:41629) is a microRNA gene on chromosome 22q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616415 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41629
Approved symbol	MIR4535
Name	microRNA 4535
Location	22q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4535
Ensembl gene	ENSG00000266887
Ensembl biotype	miRNA
Entrez	100616415
RNAcentral	URS000075A1C3 — ncRNA, 59 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580946

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580946 — 1 exons

Exon	Start	End
ENSE00002693317	48780295	48780353

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 98.43.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.43	gold quality
heart left ventricle	UBERON:0002084	82.65	gold quality
body of uterus	UBERON:0009853	74.13	gold quality
endometrium	UBERON:0001295	71.41	gold quality
nucleus accumbens	UBERON:0001882	71.27	gold quality
left ovary	UBERON:0002119	70.61	gold quality
omental fat pad	UBERON:0010414	70.44	gold quality
right frontal lobe	UBERON:0002810	68.46	gold quality
skin of abdomen	UBERON:0001416	68.41	gold quality
granulocyte	CL:0000094	67.89	gold quality
right atrium auricular region	UBERON:0006631	67.64	gold quality
ascending aorta	UBERON:0001496	67.41	gold quality
left coronary artery	UBERON:0001626	67.39	gold quality
prostate gland	UBERON:0002367	66.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.66	gold quality
skin of leg	UBERON:0001511	66.45	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.45	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.13	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.09	gold quality
anterior cingulate cortex	UBERON:0009835	66.00	gold quality
tibial nerve	UBERON:0001323	65.42	gold quality
cerebellar hemisphere	UBERON:0002245	65.32	gold quality
lung	UBERON:0002048	64.68	gold quality
hypothalamus	UBERON:0001898	64.55	gold quality
caudate nucleus	UBERON:0001873	64.36	gold quality
transverse colon	UBERON:0001157	64.27	gold quality
putamen	UBERON:0001874	64.21	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.95	gold quality
right ovary	UBERON:0002118	60.25	gold quality
pituitary gland	UBERON:0000007	57.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.