MIR4537

Summary

MIR4537 (microRNA 4537, HGNC:41682) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616422 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41682
Approved symbol	MIR4537
Name	microRNA 4537
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4537
Ensembl gene	ENSG00000264781
Ensembl biotype	miRNA
Entrez	100616422
RNAcentral	URS00007E3603 — ncRNA, 70 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581717

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581717 — 1 exons

Exon	Start	End
ENSE00002689254	105859484	105859553

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 99.53.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0063 / max 3.0917, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
145289	0.0063	2

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	99.53	gold quality
duodenum	UBERON:0002114	99.48	gold quality
granulocyte	CL:0000094	99.38	gold quality
spleen	UBERON:0002106	99.23	gold quality
lymph node	UBERON:0000029	99.20	gold quality
tonsil	UBERON:0002372	98.25	gold quality
bone marrow	UBERON:0002371	97.04	gold quality
small intestine	UBERON:0002108	96.68	gold quality
small intestine Peyer’s patch	UBERON:0003454	96.33	gold quality
mucosa of transverse colon	UBERON:0004991	95.33	gold quality
blood	UBERON:0000178	94.18	gold quality
saliva-secreting gland	UBERON:0001044	94.11	gold quality
transverse colon	UBERON:0001157	93.98	gold quality
minor salivary gland	UBERON:0001830	93.81	gold quality
fundus of stomach	UBERON:0001160	93.03	gold quality
rectum	UBERON:0001052	92.60	gold quality
intestine	UBERON:0000160	92.46	gold quality
colon	UBERON:0001155	90.16	gold quality
body of stomach	UBERON:0001161	89.91	gold quality
stomach	UBERON:0000945	89.53	gold quality
gall bladder	UBERON:0002110	87.57	gold quality
urinary bladder	UBERON:0001255	86.36	gold quality
leukocyte	CL:0000738	83.31	gold quality
left uterine tube	UBERON:0001303	83.26	gold quality
monocyte	CL:0000576	82.89	gold quality
endocervix	UBERON:0000458	82.20	gold quality
lung	UBERON:0002048	81.61	gold quality
thoracic mammary gland	UBERON:0005200	81.23	gold quality
upper lobe of left lung	UBERON:0008952	79.94	gold quality
liver	UBERON:0002107	79.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells. (PMID:34670480)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.