MIR4538

Summary

MIR4538 (microRNA 4538, HGNC:41664) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616276 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41664
Approved symbol	MIR4538
Name	microRNA 4538
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4538
Ensembl gene	ENSG00000263413
Ensembl biotype	miRNA
Entrez	100616276
RNAcentral	URS00007E49E4 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581377

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581377 — 1 exons

Exon	Start	End
ENSE00002708687	105858165	105858242

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 98.70.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0442 / max 10.1853, expressed in 18 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
145288	0.0442	18

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	98.70	gold quality
duodenum	UBERON:0002114	97.94	gold quality
spleen	UBERON:0002106	97.92	gold quality
lymph node	UBERON:0000029	96.78	gold quality
granulocyte	CL:0000094	95.74	gold quality
tonsil	UBERON:0002372	94.42	gold quality
small intestine	UBERON:0002108	92.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	92.17	gold quality
mucosa of transverse colon	UBERON:0004991	88.89	gold quality
blood	UBERON:0000178	88.65	gold quality
intestine	UBERON:0000160	88.09	gold quality
bone marrow	UBERON:0002371	88.05	gold quality
transverse colon	UBERON:0001157	87.90	gold quality
fundus of stomach	UBERON:0001160	87.25	gold quality
colon	UBERON:0001155	85.82	gold quality
saliva-secreting gland	UBERON:0001044	84.51	gold quality
stomach	UBERON:0000945	84.17	gold quality
minor salivary gland	UBERON:0001830	84.17	gold quality
body of stomach	UBERON:0001161	83.39	gold quality
leukocyte	CL:0000738	80.26	gold quality
monocyte	CL:0000576	79.57	gold quality
urinary bladder	UBERON:0001255	79.40	gold quality
multicellular organism	UBERON:0000468	77.36	gold quality
liver	UBERON:0002107	76.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	76.50	gold quality
endometrium	UBERON:0001295	75.34	gold quality
rectum	UBERON:0001052	75.30	gold quality
gall bladder	UBERON:0002110	75.10	gold quality
right lobe of liver	UBERON:0001114	74.29	gold quality
lung	UBERON:0002048	73.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.