MIR454

Summary

MIR454 (microRNA 454, HGNC:33137) is a microRNA gene on chromosome 17q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768216 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33137
Approved symbol	MIR454
Name	microRNA 454
Location	17q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-454
Ensembl gene	ENSG00000211514
Ensembl biotype	miRNA
Entrez	768216
RNAcentral	URS000070F95C — miRNA, 115 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390180

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390180 — 1 exons

Exon	Start	End
ENSE00001507607	59137758	59137872

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 79.41.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.41	gold quality
kidney	UBERON:0002113	78.31	gold quality
fundus of stomach	UBERON:0001160	77.51	gold quality
monocyte	CL:0000576	76.09	gold quality
stomach	UBERON:0000945	74.55	gold quality
lung	UBERON:0002048	74.26	gold quality
liver	UBERON:0002107	73.91	gold quality
muscle of leg	UBERON:0001383	73.12	gold quality
gastrocnemius	UBERON:0001388	73.01	gold quality
endometrium	UBERON:0001295	72.66	gold quality
calcaneal tendon	UBERON:0003701	72.62	gold quality
islet of Langerhans	UBERON:0000006	72.36	gold quality
body of pancreas	UBERON:0001150	71.44	gold quality
placenta	UBERON:0001987	71.10	gold quality
left uterine tube	UBERON:0001303	71.01	gold quality
ectocervix	UBERON:0012249	70.95	gold quality
heart	UBERON:0000948	70.52	gold quality
adrenal tissue	UBERON:0018303	70.14	gold quality
intestine	UBERON:0000160	69.88	gold quality
right atrium auricular region	UBERON:0006631	69.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.66	gold quality
body of stomach	UBERON:0001161	68.44	gold quality
tibial artery	UBERON:0007610	68.44	gold quality
midbrain	UBERON:0001891	68.39	gold quality
substantia nigra	UBERON:0002038	68.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.36	gold quality
lymph node	UBERON:0000029	68.19	gold quality
esophagus mucosa	UBERON:0002469	68.17	gold quality
colon	UBERON:0001155	68.07	gold quality
left adrenal gland	UBERON:0001234	67.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miRNA-454 was inversely correlated with severe knee or hip osteoarthritis. (PMID:24515954)
• All the results suggested that miR-454 could provide a novel therapeutic approach for treating liver fibrosis, especially the liver fibrosis induced by Schistosoma japonicum. (PMID:24685242)
• Down-regulation of BTG1 by miR-454-3p renders tumor cells sensitive to radiation. (PMID:25115181)
• High MiR-454 expression is associated with colorectal cancer. (PMID:25824771)
• Reduced expression of miR-454 in osteosarcoma cells promoted tumor growth by targeting c-Met, thus miR-454 may be a potential therapy target for this tumor. (PMID:25880599)
• Knockdown of miR-454 inhibited HCC cell proliferation and invasion and epithelial mesenchymal transition (EMT), whereas overexpression of miR-454 promoted HCC cell proliferation and invasion and EMT. (PMID:26287602)
• miR-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 expression. (PMID:26297548)
• we show that fenofibrate, a PPAR-alpha agonist, increased the expression of miR-301a/miR-454 and SKA2 in human microvascular endothelial cell line (HMEC) cells; the former were responsible for reduced expression of ET-1 and PAI-1 (PMID:26460070)
• Up-regulation of miR-454 was associated with poorer prognosis in hepatocellular carcinoma patients. (PMID:27010136)
• PTEN was confirmed as a direct target of miR-454. (PMID:27261580)
• these findings indicated that miR-454 is a potential predictor of prognosis and chemotherapy response in triple-negative breast cancer (PMID:27588500)
• STAT3 and ATG12 are targets of miR-454-3p. (PMID:28182000)
• MicroRNA-454 promotes prostate cancer cell proliferation and neoplasm invasion by down-regulation of NDRG2. (PMID:29080452)
• CHD5 was identified as a direct target of miR-454. CHD5 was downregulated in GC tissues/cell lines and the expresssion of CHD5 inversely correlated with the level of miR-454 in GC tissues. Taken together, these observations indicate that HDAC3 is associated with GC cell growth via the miR-454-mediated targeting of CHD5. (PMID:29115379)
• These findings indicated that the overexpression of miR4543p inhibited cell proliferation, migration and invasion by downregulating CPEB1. (PMID:30106109)
• miR-454 promotes the proliferation and invasion of trophoblast cells by inhibiting EPHB4 expression. (PMID:30138897)
• miR-454-3p and miR-374b-5p negatively regulated invasion and migration of Bladder cancer cell lines via targeting ZEB2. (PMID:30352837)
• MiR-454 expression is down-regulated in the placental tissues from pre-eclampsia patients.MiR-454 promotes the proliferation and invasion of trophoblast cells by down-regulation of ALK7. (PMID:30367833)
• Results show that miR-454 was significantly downregulated in tumor tissues, while it was remarkably upregulated in exosomes from the same patients with glioma. MIR-454 expression was associated with poor prognosis. Restored expression of miR-454 suppressed cell proliferation, migration, invasion, and autophagy in glioma. Data indicate that miR-454 may serve as an exosomal biomarker for glioma diagnosis. (PMID:30413650)
• miR-454-3p is overexpressed in the tumor tissues in patients with colorectal cancer and participates in the progression of colorectal cancer by promoting cancer cell proliferation, invasion, and liver metastasis. miR-454-3p may serve as a novel biomarker for colorectal cancer diagnosis and prognostic evaluation. (PMID:30613008)
• Results suggest that CALB1 is a direct target of miR-454-3p and downregulation of CALB1 by miR-454-3p suppressed NSCLC cell functions (PMID:30638403)
• The Wnt/beta-catenin signaling antagonist RPRD1A was downregulated and its upstream regulator miR-454-3p was amplified and overexpressed in metastatic breast cancer, and both were correlated with overall and relapse-free survival in breast cancer patients. (PMID:30809286)
• Data found that miR-454-3p expression was significantly decreased in both glioblastoma (GBM) tissues and cultured cell lines. Its overexpression suppressed cell proliferation and induced apoptosis of GBM. miR-454-3p executed the tumor suppressive activity via downregulating NFATc2 in GBM. (PMID:31181312)
• miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3. (PMID:31270028)
• LncRNA XIST interacts with miR-454 to inhibit cells proliferation, epithelial mesenchymal transition and induces apoptosis in triple-negative breast cancer. (PMID:32098924)
• microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6. (PMID:32165166)
• miR-454 performs tumor-promoting effects in oral squamous cell carcinoma via reducing NR3C2. (PMID:32170966)
• Long Noncoding RNA HOXA11-AS Modulates the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin via miR-454-3p/c-Met. (PMID:33115978)
• Long noncoding RNA CASC19 promotes glioma progression by modulating the miR4543p/RAB5A axis and is associated with unfavorable MRI features. (PMID:33416169)
• Long non-coding RNA SNHG1 stimulates ovarian cancer progression by modulating expression of miR-454 and ZEB1. (PMID:33641229)
• miR4543p inhibits nonsmall cell lung cancer cell proliferation and metastasis by targeting TGFB2. (PMID:33760169)
• Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip. (PMID:33820867)
• Bioinformatics analysis of mRNA and miRNA microarray to identify the key miRNA-mRNA pairs in cisplatin-resistant ovarian cancer. (PMID:33892654)
• microRNA-454-mediated NEDD4-2/TrkA/cAMP axis in heart failure: Mechanisms and cardioprotective implications. (PMID:33949117)
• MicroRNA4545p promotes breast cancer progression by inducing epithelialmesenchymal transition via targeting the FoxJ2/Ecadherin axis. (PMID:33982790)
• LncRNA MEG8 promotes TNF-alpha expression by sponging miR-454-3p in bone-invasive pituitary adenomas. (PMID:34016788)
• Alteration of miR-362-5p and miR-454-3p expression elicits diverse responses in breast cancer cell lines. (PMID:34727290)
• Association between circulating MicroRNAs (hsa-miR-92a-1* and hsa-miR-454) and multiple sclerosis phenotypes and activity status. (PMID:35436050)
• LINC00839 Promotes Neuroblastoma Progression by Sponging miR-454-3p to Up-Regulate NEUROD1. (PMID:35606572)
• MicroRNA-454 modulates the oxidative stress and neuronal apoptosis after cerebral ischemia/reperfusion injury via targeting NADPH oxidase 4 (NOX4). (PMID:36043333)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir454a	ENSDARG00000082262

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.