MIR4540

Summary

MIR4540 (microRNA 4540, HGNC:41670) is a microRNA gene on chromosome 9p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616278 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41670
Approved symbol	MIR4540
Name	microRNA 4540
Location	9p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4540
Ensembl gene	ENSG00000264922
Ensembl biotype	miRNA
Entrez	100616278
RNAcentral	URS000075BBC5 — miRNA, 55 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583532

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583532 — 1 exons

Exon	Start	End
ENSE00002727029	36864254	36864308

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 78.70.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	78.70	gold quality
blood	UBERON:0000178	78.26	gold quality
lymph node	UBERON:0000029	76.52	gold quality
cerebellar hemisphere	UBERON:0002245	67.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.63	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.74	gold quality
esophagus mucosa	UBERON:0002469	60.97	gold quality
spleen	UBERON:0002106	60.64	gold quality
colon	UBERON:0001155	51.27	gold quality
testis	UBERON:0000473	48.43	gold quality
right testis	UBERON:0004534	46.00	gold quality
left testis	UBERON:0004533	45.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.