MIR4632

Summary

MIR4632 (microRNA 4632, HGNC:41593) is a microRNA gene on chromosome 1p36.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616438 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41593
Approved symbol	MIR4632
Name	microRNA 4632
Location	1p36.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4632
Ensembl gene	ENSG00000263676
Ensembl biotype	miRNA
Entrez	100616438
RNAcentral	URS0000759A2A — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584158

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584158 — 1 exons

Exon	Start	End
ENSE00002705738	12191713	12191773

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 85.76.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.76	gold quality
adrenal tissue	UBERON:0018303	79.29	gold quality
monocyte	CL:0000576	78.48	gold quality
placenta	UBERON:0001987	78.02	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.48	gold quality
muscle of leg	UBERON:0001383	74.97	gold quality
gastrocnemius	UBERON:0001388	74.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.61	gold quality
granulocyte	CL:0000094	73.22	gold quality
right atrium auricular region	UBERON:0006631	71.83	gold quality
multicellular organism	UBERON:0000468	71.62	gold quality
liver	UBERON:0002107	71.49	gold quality
heart	UBERON:0000948	71.20	gold quality
ectocervix	UBERON:0012249	70.88	gold quality
anterior cingulate cortex	UBERON:0009835	70.84	gold quality
heart left ventricle	UBERON:0002084	70.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.47	gold quality
ascending aorta	UBERON:0001496	70.44	gold quality
left coronary artery	UBERON:0001626	70.42	gold quality
omental fat pad	UBERON:0010414	70.01	gold quality
adipose tissue	UBERON:0001013	69.68	gold quality
body of stomach	UBERON:0001161	69.61	gold quality
Ammon’s horn	UBERON:0001954	69.60	gold quality
thoracic mammary gland	UBERON:0005200	69.53	gold quality
upper lobe of left lung	UBERON:0008952	69.22	gold quality
right lobe of liver	UBERON:0001114	69.10	gold quality
tibial artery	UBERON:0007610	69.04	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.01	gold quality
lung	UBERON:0002048	68.93	gold quality
myometrium	UBERON:0001296	68.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Overall, our results suggest that miR-4632 plays an important role in regulating HPASMC proliferation and apoptosis by suppression of cJUN, providing a novel therapeutic miRNA candidate for the treatment of pulmonary vascular remodeling diseases. It also implies that serum miR-4632 has the potential to serve as a circulating biomarker for PAH diagnosis. (PMID:28701355)
• Involvement of miR-3180-3p and miR-4632-5p in palmitic acid-induced insulin resistance. (PMID:34157350)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.