MIR4633

Summary

MIR4633 (microRNA 4633, HGNC:41822) is a microRNA gene on chromosome 5q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616175 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41822
Approved symbol	MIR4633
Name	microRNA 4633
Location	5q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4633
Ensembl gene	ENSG00000264563
Ensembl biotype	miRNA
Entrez	100616175
RNAcentral	URS000075C747 — ncRNA, 79 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584064

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584064 — 1 exons

Exon	Start	End
ENSE00002698860	129097688	129097766

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 80.63.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	80.63	gold quality
endometrium	UBERON:0001295	79.00	gold quality
monocyte	CL:0000576	75.47	gold quality
right lobe of liver	UBERON:0001114	74.33	gold quality
blood	UBERON:0000178	74.02	gold quality
islet of Langerhans	UBERON:0000006	73.86	gold quality
ectocervix	UBERON:0012249	73.01	gold quality
gastrocnemius	UBERON:0001388	72.00	gold quality
heart left ventricle	UBERON:0002084	70.96	gold quality
smooth muscle tissue	UBERON:0001135	70.60	gold quality
left adrenal gland cortex	UBERON:0035825	70.16	gold quality
heart	UBERON:0000948	69.94	gold quality
body of pancreas	UBERON:0001150	69.42	gold quality
right atrium auricular region	UBERON:0006631	68.68	gold quality
left coronary artery	UBERON:0001626	67.63	gold quality
left uterine tube	UBERON:0001303	67.24	gold quality
tibial artery	UBERON:0007610	67.23	gold quality
thoracic aorta	UBERON:0001515	67.15	gold quality
ascending aorta	UBERON:0001496	66.91	gold quality
right coronary artery	UBERON:0001625	66.88	gold quality
right ovary	UBERON:0002118	66.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.61	gold quality
left adrenal gland	UBERON:0001234	66.55	gold quality
body of uterus	UBERON:0009853	66.02	gold quality
body of stomach	UBERON:0001161	65.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.83	gold quality
transverse colon	UBERON:0001157	65.51	gold quality
colon	UBERON:0001155	64.68	gold quality
fallopian tube	UBERON:0003889	64.65	gold quality
omental fat pad	UBERON:0010414	64.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Overexpression of miR-4633-5p suppressed the growth and invasiveness of melanoma cells through inhibiting activation of Akt pathway and secretion of MMP2, while knockdown of miR-4633-5p reversed the inhibitory effects. (PMID:30205394)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.