MIR4634

Summary

MIR4634 (microRNA 4634, HGNC:41559) is a microRNA gene on chromosome 5q35.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616202 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41559
Approved symbol	MIR4634
Name	microRNA 4634
Location	5q35.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4634
Ensembl gene	ENSG00000266890
Ensembl biotype	miRNA
Entrez	100616202
RNAcentral	URS000075B78C — miRNA, 54 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583531

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583531 — 1 exons

Exon	Start	End
ENSE00002726067	174751734	174751787

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 71.39.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagogastric junction muscularis propria	UBERON:0035841	71.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.02	gold quality
tibial artery	UBERON:0007610	69.55	gold quality
monocyte	CL:0000576	68.50	gold quality
amygdala	UBERON:0001876	67.92	gold quality
anterior cingulate cortex	UBERON:0009835	67.49	gold quality
ascending aorta	UBERON:0001496	67.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.68	gold quality
cerebellar hemisphere	UBERON:0002245	65.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.00	gold quality
urinary bladder	UBERON:0001255	64.63	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.02	gold quality
nucleus accumbens	UBERON:0001882	63.52	gold quality
skin of leg	UBERON:0001511	63.43	gold quality
caudate nucleus	UBERON:0001873	62.56	gold quality
pituitary gland	UBERON:0000007	62.53	gold quality
prostate gland	UBERON:0002367	57.30	gold quality
right testis	UBERON:0004534	52.84	gold quality
testis	UBERON:0000473	50.46	gold quality
left testis	UBERON:0004533	50.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.