MIR4635

Summary

MIR4635 (microRNA 4635, HGNC:41748) is a microRNA gene on chromosome 5p15.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616479 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41748
Approved symbol	MIR4635
Name	microRNA 4635
Location	5p15.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4635
Ensembl gene	ENSG00000263834
Ensembl biotype	miRNA
Entrez	100616479
RNAcentral	URS000075C84B — ncRNA, 79 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583759

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583759 — 1 exons

Exon	Start	End
ENSE00002719838	1062896	1062974

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 94.38.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	94.38	gold quality
metanephros cortex	UBERON:0010533	90.67	gold quality
upper lobe of left lung	UBERON:0008952	88.60	gold quality
lung	UBERON:0002048	87.77	gold quality
sural nerve	UBERON:0015488	85.98	gold quality
endometrium	UBERON:0001295	85.95	gold quality
skeletal muscle tissue	UBERON:0001134	85.08	gold quality
small intestine	UBERON:0002108	84.58	gold quality
small intestine Peyer’s patch	UBERON:0003454	83.49	gold quality
liver	UBERON:0002107	83.36	gold quality
right lobe of liver	UBERON:0001114	83.30	gold quality
kidney	UBERON:0002113	82.77	gold quality
bone marrow	UBERON:0002371	82.20	gold quality
right lung	UBERON:0002167	81.47	gold quality
vermiform appendix	UBERON:0001154	81.15	gold quality
adult mammalian kidney	UBERON:0000082	81.14	gold quality
prefrontal cortex	UBERON:0000451	80.65	gold quality
placenta	UBERON:0001987	80.65	gold quality
body of stomach	UBERON:0001161	80.59	gold quality
stomach	UBERON:0000945	80.54	gold quality
body of pancreas	UBERON:0001150	79.92	gold quality
pancreas	UBERON:0001264	79.84	gold quality
mucosa of transverse colon	UBERON:0004991	79.44	gold quality
fundus of stomach	UBERON:0001160	79.20	gold quality
transverse colon	UBERON:0001157	78.99	gold quality
intestine	UBERON:0000160	78.76	gold quality
apex of heart	UBERON:0002098	77.81	gold quality
monocyte	CL:0000576	77.70	gold quality
heart left ventricle	UBERON:0002084	77.17	gold quality
blood	UBERON:0000178	76.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.