MIR4636

Summary

MIR4636 (microRNA 4636, HGNC:41798) is a microRNA gene on chromosome 5p15.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616326 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41798
Approved symbol	MIR4636
Name	microRNA 4636
Location	5p15.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4636
Ensembl gene	ENSG00000266415
Ensembl biotype	miRNA
Entrez	100616326
RNAcentral	URS000075A2B1 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582271

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582271 — 1 exons

Exon	Start	End
ENSE00002704599	9053816	9053895

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 82.66.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.66	gold quality
endometrium	UBERON:0001295	75.34	gold quality
gastrocnemius	UBERON:0001388	72.85	gold quality
spleen	UBERON:0002106	71.93	gold quality
heart left ventricle	UBERON:0002084	70.87	gold quality
heart	UBERON:0000948	70.86	gold quality
adult mammalian kidney	UBERON:0000082	70.81	gold quality
stomach	UBERON:0000945	70.06	gold quality
myometrium	UBERON:0001296	69.69	gold quality
islet of Langerhans	UBERON:0000006	69.49	gold quality
anterior cingulate cortex	UBERON:0009835	68.98	gold quality
kidney	UBERON:0002113	67.66	gold quality
gall bladder	UBERON:0002110	67.04	gold quality
right atrium auricular region	UBERON:0006631	66.44	gold quality
intestine	UBERON:0000160	66.37	gold quality
ascending aorta	UBERON:0001496	65.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.64	gold quality
lung	UBERON:0002048	65.58	gold quality
transverse colon	UBERON:0001157	65.39	gold quality
left ovary	UBERON:0002119	65.30	gold quality
small intestine	UBERON:0002108	65.10	gold quality
skin of leg	UBERON:0001511	65.09	gold quality
ectocervix	UBERON:0012249	65.04	gold quality
omental fat pad	UBERON:0010414	64.80	gold quality
colon	UBERON:0001155	64.49	gold quality
esophagus mucosa	UBERON:0002469	64.28	gold quality
mucosa of transverse colon	UBERON:0004991	64.12	gold quality
vagina	UBERON:0000996	64.08	gold quality
testis	UBERON:0000473	63.65	gold quality
tibial nerve	UBERON:0001323	63.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Peripheral blood circulating microRNA-4636/-143 for the prognosis of cervical cancer. (PMID:31407404)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.