MIR4638

Summary

MIR4638 (microRNA 4638, HGNC:41841) is a microRNA gene on chromosome 5q35.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616342 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41841
Approved symbol	MIR4638
Name	microRNA 4638
Location	5q35.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4638
Ensembl gene	ENSG00000264732
Ensembl biotype	miRNA
Entrez	100616342
RNAcentral	URS000075F002 — ncRNA, 68 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581158

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581158 — 1 exons

Exon	Start	End
ENSE00002697412	181222566	181222633

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 64.29.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	64.29	gold quality
left ovary	UBERON:0002119	62.55	gold quality
thyroid gland	UBERON:0002046	60.92	gold quality
cerebellar hemisphere	UBERON:0002245	58.48	gold quality
tibial nerve	UBERON:0001323	56.78	gold quality
left testis	UBERON:0004533	39.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• functional role of miR-4638-5p and its downstream genes/pathways have the potential to develop biomarkers for castration resistant prostate cancer (CRPC) onset. (PMID:27329728)
• In vivo validation of the functional role of MicroRNA-4638-3p in breast cancer bone metastasis. (PMID:38300343)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.