MIR4639

Summary

MIR4639 (microRNA 4639, HGNC:41645) is a microRNA gene on chromosome 6p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616269 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41645
Approved symbol	MIR4639
Name	microRNA 4639
Location	6p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4639
Ensembl gene	ENSG00000263712
Ensembl biotype	miRNA
Entrez	100616269
RNAcentral	URS000075D0AD — ncRNA, 69 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584938

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584938 — 1 exons

Exon	Start	End
ENSE00002685534	16141556	16141624

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 91.02.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	91.02	gold quality
calcaneal tendon	UBERON:0003701	89.59	gold quality
skeletal muscle tissue	UBERON:0001134	88.60	gold quality
duodenum	UBERON:0002114	85.92	gold quality
vermiform appendix	UBERON:0001154	84.39	gold quality
monocyte	CL:0000576	83.06	gold quality
placenta	UBERON:0001987	82.52	gold quality
endometrium	UBERON:0001295	81.65	gold quality
adrenal tissue	UBERON:0018303	81.07	gold quality
blood	UBERON:0000178	80.21	gold quality
prefrontal cortex	UBERON:0000451	78.35	gold quality
lymph node	UBERON:0000029	77.18	gold quality
left lobe of thyroid gland	UBERON:0001120	77.07	gold quality
thyroid gland	UBERON:0002046	76.96	gold quality
muscle of leg	UBERON:0001383	76.20	gold quality
gastrocnemius	UBERON:0001388	75.49	gold quality
left uterine tube	UBERON:0001303	75.45	gold quality
right lobe of thyroid gland	UBERON:0001119	75.33	gold quality
ascending aorta	UBERON:0001496	74.95	gold quality
kidney	UBERON:0002113	74.74	gold quality
thoracic aorta	UBERON:0001515	74.69	gold quality
urinary bladder	UBERON:0001255	74.52	gold quality
lung	UBERON:0002048	74.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.04	gold quality
saliva-secreting gland	UBERON:0001044	73.97	gold quality
body of stomach	UBERON:0001161	73.72	gold quality
stomach	UBERON:0000945	73.69	gold quality
minor salivary gland	UBERON:0001830	73.67	gold quality
islet of Langerhans	UBERON:0000006	73.63	gold quality
skin of abdomen	UBERON:0001416	73.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Bioinformatics analysis results indicated that the two SNPs located at the 3’-UTR of BMP2 might alter the binding ability of miR-1273d and miR-4639- 5p in patients with non-syndromic tooth agenesis. (PMID:27362534)
• Regulation of Hsa-miR-4639-5p expression and its potential role in the pathogenesis of Parkinson’s disease. (PMID:37101349)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.