MIR4640

Summary

MIR4640 (microRNA 4640, HGNC:41561) is a microRNA gene on chromosome 6p21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616237 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41561
Approved symbol	MIR4640
Name	microRNA 4640
Location	6p21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4640
Ensembl gene	ENSG00000284370
Ensembl biotype	miRNA
Entrez	100616237
RNAcentral	URS000075D4A6 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581824

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581824 — 1 exons

Exon	Start	End
ENSE00002715760	30890883	30890972

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 70.85.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	70.85	gold quality
putamen	UBERON:0001874	69.73	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.19	gold quality
left coronary artery	UBERON:0001626	66.26	gold quality
descending thoracic aorta	UBERON:0002345	66.17	gold quality
heart left ventricle	UBERON:0002084	65.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.16	gold quality
smooth muscle tissue	UBERON:0001135	65.05	gold quality
body of stomach	UBERON:0001161	64.84	gold quality
thoracic aorta	UBERON:0001515	64.83	gold quality
adult mammalian kidney	UBERON:0000082	64.64	gold quality
Ammon’s horn	UBERON:0001954	64.61	gold quality
right atrium auricular region	UBERON:0006631	64.54	gold quality
ascending aorta	UBERON:0001496	64.15	gold quality
tibial artery	UBERON:0007610	64.01	gold quality
omental fat pad	UBERON:0010414	63.90	gold quality
stomach	UBERON:0000945	63.78	gold quality
right frontal lobe	UBERON:0002810	63.62	gold quality
nucleus accumbens	UBERON:0001882	62.90	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.61	gold quality
body of pancreas	UBERON:0001150	62.58	gold quality
fundus of stomach	UBERON:0001160	62.50	gold quality
spleen	UBERON:0002106	62.26	gold quality
transverse colon	UBERON:0001157	61.72	gold quality
blood	UBERON:0000178	61.17	gold quality
cerebellar hemisphere	UBERON:0002245	60.91	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.68	gold quality
amygdala	UBERON:0001876	60.49	gold quality
vagina	UBERON:0000996	59.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.