MIR4641

Summary

MIR4641 (microRNA 4641, HGNC:41835) is a microRNA gene on chromosome 6p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616178 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41835
Approved symbol	MIR4641
Name	microRNA 4641
Location	6p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4641
Ensembl gene	ENSG00000266494
Ensembl biotype	miRNA
Entrez	100616178
RNAcentral	URS000075E7ED — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578353

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578353 — 1 exons

Exon	Start	End
ENSE00002702200	41598723	41598788

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 81.82.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	81.82	gold quality
bone marrow	UBERON:0002371	80.46	gold quality
placenta	UBERON:0001987	78.94	gold quality
prefrontal cortex	UBERON:0000451	76.57	gold quality
monocyte	CL:0000576	76.29	gold quality
muscle of leg	UBERON:0001383	74.93	gold quality
rectum	UBERON:0001052	74.70	gold quality
blood	UBERON:0000178	74.66	gold quality
calcaneal tendon	UBERON:0003701	74.29	gold quality
gastrocnemius	UBERON:0001388	73.83	gold quality
stomach	UBERON:0000945	73.71	gold quality
body of stomach	UBERON:0001161	73.59	gold quality
right lobe of liver	UBERON:0001114	73.52	gold quality
heart left ventricle	UBERON:0002084	71.99	gold quality
liver	UBERON:0002107	71.76	gold quality
islet of Langerhans	UBERON:0000006	71.39	gold quality
right adrenal gland cortex	UBERON:0035827	71.08	gold quality
right atrium auricular region	UBERON:0006631	71.02	gold quality
body of pancreas	UBERON:0001150	69.60	gold quality
left adrenal gland cortex	UBERON:0035825	68.68	gold quality
tibial artery	UBERON:0007610	68.39	gold quality
frontal cortex	UBERON:0001870	68.32	gold quality
ascending aorta	UBERON:0001496	68.23	gold quality
right lobe of thyroid gland	UBERON:0001119	68.22	gold quality
Ammon’s horn	UBERON:0001954	67.84	gold quality
adult mammalian kidney	UBERON:0000082	67.82	gold quality
left coronary artery	UBERON:0001626	67.71	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.65	gold quality
substantia nigra	UBERON:0002038	67.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• circC3P1 acts as a tumor suppressor via enhancing PCK1 expression by sponging miR-4641 in hepatocellular carcinoma. (PMID:29608893)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.