MIR4642

Summary

MIR4642 (microRNA 4642, HGNC:41865) is a microRNA gene on chromosome 6p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616352 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41865
Approved symbol	MIR4642
Name	microRNA 4642
Location	6p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4642
Ensembl gene	ENSG00000266619
Ensembl biotype	miRNA
Entrez	100616352
RNAcentral	URS000075AC90 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583943

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583943 — 1 exons

Exon	Start	End
ENSE00002699233	44435641	44435722

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 79.69.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	79.69	gold quality
blood	UBERON:0000178	78.62	gold quality
calcaneal tendon	UBERON:0003701	78.38	gold quality
monocyte	CL:0000576	76.45	gold quality
kidney	UBERON:0002113	74.84	gold quality
muscle of leg	UBERON:0001383	74.73	gold quality
right ovary	UBERON:0002118	72.88	gold quality
gastrocnemius	UBERON:0001388	72.86	gold quality
amygdala	UBERON:0001876	72.56	gold quality
adult mammalian kidney	UBERON:0000082	72.11	gold quality
stomach	UBERON:0000945	69.62	gold quality
putamen	UBERON:0001874	69.30	gold quality
tibial artery	UBERON:0007610	69.26	gold quality
body of stomach	UBERON:0001161	69.06	gold quality
body of pancreas	UBERON:0001150	67.93	gold quality
liver	UBERON:0002107	67.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.22	gold quality
urinary bladder	UBERON:0001255	66.08	gold quality
endometrium	UBERON:0001295	65.97	gold quality
lung	UBERON:0002048	65.91	gold quality
left adrenal gland	UBERON:0001234	65.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.64	gold quality
right lobe of liver	UBERON:0001114	65.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.42	gold quality
ascending aorta	UBERON:0001496	65.22	gold quality
transverse colon	UBERON:0001157	65.19	gold quality
Ammon’s horn	UBERON:0001954	65.19	gold quality
adenohypophysis	UBERON:0002196	65.18	gold quality
right atrium auricular region	UBERON:0006631	64.93	gold quality
intestine	UBERON:0000160	64.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.