MIR4643

Summary

MIR4643 (microRNA 4643, HGNC:41814) is a microRNA gene on chromosome 6q15.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616174 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41814
Approved symbol	MIR4643
Name	microRNA 4643
Location	6q15
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4643
Ensembl gene	ENSG00000263734
Ensembl biotype	miRNA
Entrez	100616174
RNAcentral	URS000075B78A — ncRNA, 78 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577473

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577473 — 1 exons

Exon	Start	End
ENSE00002686158	91521660	91521737

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 79.93.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	79.93	gold quality
heart	UBERON:0000948	73.95	gold quality
right frontal lobe	UBERON:0002810	72.73	gold quality
lung	UBERON:0002048	71.24	gold quality
heart left ventricle	UBERON:0002084	71.16	gold quality
stomach	UBERON:0000945	70.73	gold quality
intestine	UBERON:0000160	70.19	gold quality
right atrium auricular region	UBERON:0006631	67.69	gold quality
frontal cortex	UBERON:0001870	67.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.77	gold quality
colon	UBERON:0001155	65.82	gold quality
nucleus accumbens	UBERON:0001882	64.42	gold quality
anterior cingulate cortex	UBERON:0009835	64.31	gold quality
tibial nerve	UBERON:0001323	64.25	gold quality
amygdala	UBERON:0001876	63.69	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.55	gold quality
Ammon’s horn	UBERON:0001954	63.02	gold quality
thyroid gland	UBERON:0002046	59.51	gold quality
prostate gland	UBERON:0002367	59.00	gold quality
left lobe of thyroid gland	UBERON:0001120	58.21	gold quality
right testis	UBERON:0004534	44.79	gold quality
left testis	UBERON:0004533	44.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.