MIR4644

Summary

MIR4644 (microRNA 4644, HGNC:41687) is a microRNA gene on chromosome 6q27.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616430 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41687
Approved symbol	MIR4644
Name	microRNA 4644
Location	6q27
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4644
Ensembl gene	ENSG00000266245
Ensembl biotype	miRNA
Entrez	100616430
RNAcentral	URS0000759E97 — ncRNA, 84 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579929

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579929 — 1 exons

Exon	Start	End
ENSE00002693544	170330761	170330844

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 88.14.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	88.14	gold quality
adrenal tissue	UBERON:0018303	83.97	gold quality
corpus callosum	UBERON:0002336	80.53	gold quality
bone marrow	UBERON:0002371	79.41	gold quality
blood	UBERON:0000178	78.44	gold quality
monocyte	CL:0000576	76.37	gold quality
stomach	UBERON:0000945	74.06	gold quality
lymph node	UBERON:0000029	73.72	gold quality
endometrium	UBERON:0001295	73.18	gold quality
gastrocnemius	UBERON:0001388	73.16	gold quality
placenta	UBERON:0001987	72.84	gold quality
liver	UBERON:0002107	72.15	gold quality
kidney	UBERON:0002113	71.88	gold quality
islet of Langerhans	UBERON:0000006	71.66	gold quality
adult mammalian kidney	UBERON:0000082	71.45	gold quality
fallopian tube	UBERON:0003889	70.87	gold quality
substantia nigra	UBERON:0002038	70.67	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.63	gold quality
prefrontal cortex	UBERON:0000451	70.42	gold quality
fundus of stomach	UBERON:0001160	70.26	gold quality
left uterine tube	UBERON:0001303	70.16	gold quality
heart	UBERON:0000948	70.04	gold quality
body of stomach	UBERON:0001161	69.71	gold quality
tibial artery	UBERON:0007610	69.33	gold quality
heart left ventricle	UBERON:0002084	69.29	gold quality
right atrium auricular region	UBERON:0006631	69.26	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.11	gold quality
right lobe of liver	UBERON:0001114	68.97	gold quality
endocervix	UBERON:0000458	68.93	gold quality
body of pancreas	UBERON:0001150	68.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• This pilot study suggests that miR1246 and miR4644 in salivary exosomes could be candidate biomarkers for pancreatobiliary tract cancer. (PMID:27573701)
• ELFN1-AS1 accelerates the proliferation and migration of colorectal cancer via regulation of miR-4644/TRIM44 axis. (PMID:31929141)
• Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome. (PMID:37322492)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.