MIR4645

Summary

MIR4645 (microRNA 4645, HGNC:41689) is a microRNA gene on chromosome 6p25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616285 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41689
Approved symbol	MIR4645
Name	microRNA 4645
Location	6p25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4645
Ensembl gene	ENSG00000266750
Ensembl biotype	miRNA
Entrez	100616285
RNAcentral	URS000075BC80 — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583158

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583158 — 1 exons

Exon	Start	End
ENSE00002710800	2854031	2854107

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 89.45.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	89.45	gold quality
sural nerve	UBERON:0015488	84.07	gold quality
fundus of stomach	UBERON:0001160	83.79	gold quality
adrenal tissue	UBERON:0018303	82.90	gold quality
vermiform appendix	UBERON:0001154	82.28	gold quality
leukocyte	CL:0000738	81.09	gold quality
monocyte	CL:0000576	80.74	gold quality
lymph node	UBERON:0000029	80.41	gold quality
tonsil	UBERON:0002372	79.23	gold quality
bone marrow	UBERON:0002371	78.60	gold quality
placenta	UBERON:0001987	78.23	gold quality
blood	UBERON:0000178	76.73	gold quality
endometrium	UBERON:0001295	75.61	gold quality
smooth muscle tissue	UBERON:0001135	74.97	gold quality
muscle of leg	UBERON:0001383	74.73	gold quality
adrenal gland	UBERON:0002369	74.00	gold quality
left adrenal gland	UBERON:0001234	73.67	gold quality
gastrocnemius	UBERON:0001388	73.40	gold quality
islet of Langerhans	UBERON:0000006	72.72	gold quality
right adrenal gland	UBERON:0001233	72.37	gold quality
small intestine	UBERON:0002108	72.33	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.04	gold quality
left adrenal gland cortex	UBERON:0035825	71.72	gold quality
spleen	UBERON:0002106	71.71	gold quality
right atrium auricular region	UBERON:0006631	71.11	gold quality
heart	UBERON:0000948	71.02	gold quality
heart left ventricle	UBERON:0002084	70.99	gold quality
ectocervix	UBERON:0012249	70.85	gold quality
substantia nigra	UBERON:0002038	70.65	gold quality
urinary bladder	UBERON:0001255	70.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5. (PMID:38742811)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.