MIR4646

Summary

MIR4646 (microRNA 4646, HGNC:41543) is a microRNA gene on chromosome 6p21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616230 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41543
Approved symbol	MIR4646
Name	microRNA 4646
Location	6p21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4646
Ensembl gene	ENSG00000266776
Ensembl biotype	miRNA
Entrez	100616230
RNAcentral	URS000075DE4B — ncRNA, 63 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580775

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580775 — 1 exons

Exon	Start	End
ENSE00002709737	31701029	31701091

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 84.67.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	84.67	gold quality
adrenal tissue	UBERON:0018303	81.25	gold quality
bone marrow	UBERON:0002371	80.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.45	gold quality
blood	UBERON:0000178	76.39	gold quality
right lobe of liver	UBERON:0001114	74.53	gold quality
gastrocnemius	UBERON:0001388	73.45	gold quality
stomach	UBERON:0000945	71.74	gold quality
smooth muscle tissue	UBERON:0001135	71.65	gold quality
body of stomach	UBERON:0001161	71.52	gold quality
heart left ventricle	UBERON:0002084	71.18	gold quality
heart	UBERON:0000948	70.88	gold quality
adrenal gland	UBERON:0002369	70.64	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.05	gold quality
left adrenal gland	UBERON:0001234	69.81	gold quality
body of pancreas	UBERON:0001150	69.60	gold quality
tibial artery	UBERON:0007610	68.83	gold quality
right atrium auricular region	UBERON:0006631	68.04	gold quality
right adrenal gland cortex	UBERON:0035827	68.00	gold quality
skin of leg	UBERON:0001511	67.94	gold quality
kidney	UBERON:0002113	67.87	gold quality
right uterine tube	UBERON:0001302	67.52	gold quality
ascending aorta	UBERON:0001496	67.27	gold quality
left coronary artery	UBERON:0001626	67.25	gold quality
esophagus mucosa	UBERON:0002469	67.21	gold quality
minor salivary gland	UBERON:0001830	66.91	gold quality
putamen	UBERON:0001874	66.87	gold quality
omental fat pad	UBERON:0010414	66.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.55	gold quality
thoracic mammary gland	UBERON:0005200	66.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• We identify a specific MIR4646 associated epigenetic risk site to be associated with depression in adolescents. Cg04102384 putatively regulates gene expression of MIR4646-3p. (PMID:28618313)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.