MIR4647

Summary

MIR4647 (microRNA 4647, HGNC:41594) is a microRNA gene on chromosome 6p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616124 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41594
Approved symbol	MIR4647
Name	microRNA 4647
Location	6p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4647
Ensembl gene	ENSG00000284427
Ensembl biotype	miRNA
Entrez	100616124
RNAcentral	URS000075D03E — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583964

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583964 — 1 exons

Exon	Start	End
ENSE00002710117	44254206	44254285

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 85.29.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	85.29	gold quality
blood	UBERON:0000178	80.70	gold quality
liver	UBERON:0002107	72.05	gold quality
sural nerve	UBERON:0015488	64.56	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.