MIR4648

Summary

MIR4648 (microRNA 4648, HGNC:41560) is a microRNA gene on chromosome 7p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616116 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41560
Approved symbol	MIR4648
Name	microRNA 4648
Location	7p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4648
Ensembl gene	ENSG00000264357
Ensembl biotype	miRNA
Entrez	100616116
RNAcentral	URS000075E83F — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580107

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580107 — 1 exons

Exon	Start	End
ENSE00002685925	2527074	2527145

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 89.63.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.63	gold quality
bone marrow	UBERON:0002371	89.58	gold quality
duodenum	UBERON:0002114	85.43	gold quality
skeletal muscle tissue	UBERON:0001134	85.05	gold quality
vermiform appendix	UBERON:0001154	83.72	gold quality
lymph node	UBERON:0000029	81.12	gold quality
adrenal tissue	UBERON:0018303	80.29	gold quality
blood	UBERON:0000178	80.06	gold quality
placenta	UBERON:0001987	79.06	gold quality
monocyte	CL:0000576	76.74	gold quality
prefrontal cortex	UBERON:0000451	75.38	gold quality
muscle of leg	UBERON:0001383	75.24	gold quality
granulocyte	CL:0000094	75.20	gold quality
liver	UBERON:0002107	75.11	gold quality
gall bladder	UBERON:0002110	73.46	gold quality
pancreas	UBERON:0001264	72.68	gold quality
body of pancreas	UBERON:0001150	72.41	gold quality
gastrocnemius	UBERON:0001388	72.02	gold quality
lower esophagus mucosa	UBERON:0035834	71.97	gold quality
endometrium	UBERON:0001295	71.94	gold quality
tonsil	UBERON:0002372	71.74	gold quality
heart left ventricle	UBERON:0002084	71.39	gold quality
stomach	UBERON:0000945	71.34	gold quality
body of stomach	UBERON:0001161	70.70	gold quality
adrenal gland	UBERON:0002369	70.18	gold quality
heart	UBERON:0000948	69.96	gold quality
myometrium	UBERON:0001296	69.69	gold quality
right atrium auricular region	UBERON:0006631	69.29	gold quality
right adrenal gland cortex	UBERON:0035827	69.15	gold quality
right lobe of liver	UBERON:0001114	69.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.