MIR4649

Summary

MIR4649 (microRNA 4649, HGNC:41852) is a microRNA gene on chromosome 7p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616346 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41852
Approved symbol	MIR4649
Name	microRNA 4649
Location	7p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4649
Ensembl gene	ENSG00000284412
Ensembl biotype	miRNA
Entrez	100616346
RNAcentral	URS000075ADD0 — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582839

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582839 — 1 exons

Exon	Start	End
ENSE00002707032	44110849	44110912

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 73.01.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	73.01	gold quality
lung	UBERON:0002048	70.81	gold quality
islet of Langerhans	UBERON:0000006	65.90	gold quality
blood	UBERON:0000178	61.12	gold quality
putamen	UBERON:0001874	59.61	gold quality
cerebellar hemisphere	UBERON:0002245	54.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-4649-3p is downregulated in nasopharyngeal carcinoma cell lines accompanied with SHP-1 upregulation. (PMID:26081980)
• Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase. (PMID:34546840)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.