MIR4650-1

Summary

MIR4650-1 (microRNA 4650-1, HGNC:41755) is a microRNA gene on chromosome 7q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616310 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41755
Approved symbol	MIR4650-1
Name	microRNA 4650-1
Location	7q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4650-1
Ensembl gene	ENSG00000266525
Ensembl biotype	miRNA
Entrez	100616310
RNAcentral	URS000075C015 — miRNA, 76 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579075

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579075 — 1 exons

Exon	Start	End
ENSE00002698881	67114322	67114397

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 75.29.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	75.29	gold quality
blood	UBERON:0000178	73.48	gold quality
adrenal tissue	UBERON:0018303	69.95	gold quality
calcaneal tendon	UBERON:0003701	68.20	gold quality
liver	UBERON:0002107	67.95	gold quality
gastrocnemius	UBERON:0001388	67.93	gold quality
monocyte	CL:0000576	67.55	gold quality
endometrium	UBERON:0001295	67.19	gold quality
kidney	UBERON:0002113	66.71	gold quality
stomach	UBERON:0000945	64.93	gold quality
body of pancreas	UBERON:0001150	63.59	gold quality
heart	UBERON:0000948	62.20	gold quality
right lobe of liver	UBERON:0001114	61.92	gold quality
intestine	UBERON:0000160	61.71	gold quality
heart left ventricle	UBERON:0002084	61.03	gold quality
lung	UBERON:0002048	60.87	gold quality
right atrium auricular region	UBERON:0006631	60.38	gold quality
right lobe of thyroid gland	UBERON:0001119	60.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.23	gold quality
right adrenal gland cortex	UBERON:0035827	60.13	gold quality
adult mammalian kidney	UBERON:0000082	60.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.03	gold quality
left adrenal gland cortex	UBERON:0035825	59.96	gold quality
colon	UBERON:0001155	59.90	gold quality
left adrenal gland	UBERON:0001234	59.84	gold quality
right coronary artery	UBERON:0001625	59.77	gold quality
body of stomach	UBERON:0001161	59.37	gold quality
left coronary artery	UBERON:0001626	59.25	gold quality
tibial artery	UBERON:0007610	58.96	gold quality
ascending aorta	UBERON:0001496	58.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): MIR4650-2 (ENSG00000264494)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.