MIR4651

Summary

MIR4651 (microRNA 4651, HGNC:41647) is a microRNA gene on chromosome 7q11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616270 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41647
Approved symbol	MIR4651
Name	microRNA 4651
Location	7q11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4651
Ensembl gene	ENSG00000284334
Ensembl biotype	miRNA
Entrez	100616270
RNAcentral	URS000075C716 — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582622

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582622 — 1 exons

Exon	Start	End
ENSE00002690954	75915197	75915269

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 78.08.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	78.08	gold quality
gastrocnemius	UBERON:0001388	69.29	gold quality
left adrenal gland	UBERON:0001234	63.60	gold quality
ascending aorta	UBERON:0001496	63.31	gold quality
skin of abdomen	UBERON:0001416	62.68	gold quality
Ammon’s horn	UBERON:0001954	61.75	gold quality
esophagus mucosa	UBERON:0002469	60.64	gold quality
thyroid gland	UBERON:0002046	50.57	gold quality
amygdala	UBERON:0001876	49.84	gold quality
right adrenal gland	UBERON:0001233	41.66	gold quality
right testis	UBERON:0004534	37.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• These results indicated that miR-4651 regulated Nonsense-mediated mRNA decay by targeting SMG9 mRNA. (PMID:30902786)
• MicroRNA-4651 targets bromodomain-containing protein 4 to inhibit non-small cell lung cancer cell progression. (PMID:32081805)
• MicroRNA-4651 represses hepatocellular carcinoma cell growth and facilitates apoptosis via targeting FOXP4. (PMID:32436934)
• LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO6. (PMID:34507637)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.