MIR4652

Summary

MIR4652 (microRNA 4652, HGNC:41615) is a microRNA gene on chromosome 7q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616206 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41615
Approved symbol	MIR4652
Name	microRNA 4652
Location	7q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4652
Ensembl gene	ENSG00000265423
Ensembl biotype	miRNA
Entrez	100616206
RNAcentral	URS000075DA78 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583734

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583734 — 1 exons

Exon	Start	End
ENSE00002713456	93716928	93717005

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 97.57.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.57	gold quality
adult mammalian kidney	UBERON:0000082	79.88	gold quality
endometrium	UBERON:0001295	78.95	gold quality
stomach	UBERON:0000945	75.96	gold quality
intestine	UBERON:0000160	75.84	gold quality
monocyte	CL:0000576	71.50	gold quality
transverse colon	UBERON:0001157	70.58	gold quality
right frontal lobe	UBERON:0002810	67.73	gold quality
lung	UBERON:0002048	59.41	gold quality
left testis	UBERON:0004533	35.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LINC00702/miR-4652-3p/ZEB1 axis promotes the progression of malignant meningioma through activating Wnt/beta-catenin pathway (PMID:30849635)
• SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma. (PMID:32641685)
• MiR-4652-5p Targets RND1 to Regulate Cell Adhesion and Promote Lung Squamous Cell Carcinoma Progression. (PMID:35334070)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.