MIR4653

Summary

MIR4653 (microRNA 4653, HGNC:41562) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616117 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41562
Approved symbol	MIR4653
Name	microRNA 4653
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4653
Ensembl gene	ENSG00000264425
Ensembl biotype	miRNA
Entrez	100616117
RNAcentral	URS000075C754 — ncRNA, 83 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585107

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585107 — 1 exons

Exon	Start	End
ENSE00002716299	101159473	101159555

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 91.15.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	91.15	gold quality
duodenum	UBERON:0002114	90.92	gold quality
skin of leg	UBERON:0001511	84.09	gold quality
lower esophagus mucosa	UBERON:0035834	83.53	gold quality
transverse colon	UBERON:0001157	83.07	gold quality
zone of skin	UBERON:0000014	83.03	gold quality
esophagus mucosa	UBERON:0002469	82.34	gold quality
endometrium	UBERON:0001295	81.56	gold quality
skin of abdomen	UBERON:0001416	81.54	gold quality
vermiform appendix	UBERON:0001154	80.49	gold quality
adrenal tissue	UBERON:0018303	80.02	gold quality
small intestine	UBERON:0002108	79.53	gold quality
placenta	UBERON:0001987	79.49	gold quality
calcaneal tendon	UBERON:0003701	78.97	gold quality
intestine	UBERON:0000160	78.91	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.86	gold quality
fundus of stomach	UBERON:0001160	78.81	gold quality
body of stomach	UBERON:0001161	78.63	gold quality
colon	UBERON:0001155	78.58	gold quality
stomach	UBERON:0000945	78.40	gold quality
esophagus	UBERON:0001043	77.96	gold quality
rectum	UBERON:0001052	77.73	gold quality
tonsil	UBERON:0002372	77.58	gold quality
body of pancreas	UBERON:0001150	76.89	gold quality
apex of heart	UBERON:0002098	76.76	gold quality
pancreas	UBERON:0001264	76.52	gold quality
vagina	UBERON:0000996	76.01	gold quality
metanephros cortex	UBERON:0010533	75.97	gold quality
urinary bladder	UBERON:0001255	75.89	gold quality
saliva-secreting gland	UBERON:0001044	75.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-4653-3p overexpression is associated with a poor prognosis of pancreatic ductal adenocarcinoma via HIPK2 downregulation. (PMID:36289359)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.