MIR4654

Summary

MIR4654 (microRNA 4654, HGNC:41643) is a microRNA gene on chromosome 1q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616386 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41643
Approved symbol	MIR4654
Name	microRNA 4654
Location	1q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4654
Ensembl gene	ENSG00000266144
Ensembl biotype	miRNA
Entrez	100616386
RNAcentral	URS000075A269 — miRNA, 76 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577581

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577581 — 1 exons

Exon	Start	End
ENSE00002724964	162157107	162157182

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 82.80.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	82.80	gold quality
kidney	UBERON:0002113	82.62	gold quality
blood	UBERON:0000178	80.49	gold quality
liver	UBERON:0002107	75.88	gold quality
adrenal tissue	UBERON:0018303	75.59	gold quality
stomach	UBERON:0000945	73.47	gold quality
monocyte	CL:0000576	70.40	gold quality
adult mammalian kidney	UBERON:0000082	70.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.22	gold quality
right lobe of liver	UBERON:0001114	69.81	gold quality
lung	UBERON:0002048	69.42	gold quality
body of stomach	UBERON:0001161	69.10	gold quality
intestine	UBERON:0000160	66.74	gold quality
right adrenal gland cortex	UBERON:0035827	66.10	gold quality
skin of abdomen	UBERON:0001416	65.56	gold quality
skin of leg	UBERON:0001511	65.45	gold quality
colon	UBERON:0001155	65.40	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.16	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.10	gold quality
corpus callosum	UBERON:0002336	63.74	gold quality
transverse colon	UBERON:0001157	63.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.72	gold quality
left lobe of thyroid gland	UBERON:0001120	62.69	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.10	gold quality
brain	UBERON:0000955	61.83	gold quality
cerebellar hemisphere	UBERON:0002245	61.61	gold quality
minor salivary gland	UBERON:0001830	61.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.11	gold quality
right frontal lobe	UBERON:0002810	60.17	gold quality
esophagus mucosa	UBERON:0002469	59.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Methyltransferase METTL3-mediated maturation of miR-4654 facilitates high glucose-induced apoptosis and oxidative stress in lens epithelial cells via decreasing SOD2. (PMID:38404215)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.