MIR4655

Summary

MIR4655 (microRNA 4655, HGNC:41754) is a microRNA gene on chromosome 7p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616160 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41754
Approved symbol	MIR4655
Name	microRNA 4655
Location	7p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4655
Ensembl gene	ENSG00000265089
Ensembl biotype	miRNA
Entrez	100616160
RNAcentral	URS000075EACC — ncRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580817

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580817 — 1 exons

Exon	Start	End
ENSE00002723757	1844180	1844253

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 78.40.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.40	gold quality
right lobe of liver	UBERON:0001114	78.21	gold quality
adrenal tissue	UBERON:0018303	75.93	gold quality
tibial artery	UBERON:0007610	75.16	gold quality
liver	UBERON:0002107	73.40	gold quality
body of stomach	UBERON:0001161	72.94	gold quality
gastrocnemius	UBERON:0001388	72.61	gold quality
monocyte	CL:0000576	72.40	gold quality
adult mammalian kidney	UBERON:0000082	71.86	gold quality
stomach	UBERON:0000945	70.10	gold quality
right atrium auricular region	UBERON:0006631	69.08	gold quality
left uterine tube	UBERON:0001303	68.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.30	gold quality
heart left ventricle	UBERON:0002084	68.03	gold quality
skin of abdomen	UBERON:0001416	66.72	gold quality
nucleus accumbens	UBERON:0001882	65.99	gold quality
Ammon’s horn	UBERON:0001954	65.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.59	gold quality
myometrium	UBERON:0001296	65.55	gold quality
ascending aorta	UBERON:0001496	65.52	gold quality
hypothalamus	UBERON:0001898	65.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.34	gold quality
body of pancreas	UBERON:0001150	65.29	gold quality
right frontal lobe	UBERON:0002810	65.16	gold quality
amygdala	UBERON:0001876	65.12	gold quality
putamen	UBERON:0001874	64.99	gold quality
minor salivary gland	UBERON:0001830	64.72	gold quality
zone of skin	UBERON:0000014	64.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.40	gold quality
left coronary artery	UBERON:0001626	64.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Exosome-mediated miR-4655-3p contributes to UV radiation-induced bystander effects. (PMID:35688281)
• Irradiated lung cancer cell-derived exosomes modulate macrophage polarization by inhibiting MID1 via miR-4655-5p. (PMID:36709645)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.