MIR4656

Summary

MIR4656 (microRNA 4656, HGNC:41749) is a microRNA gene on chromosome 7p22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616465 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41749
Approved symbol	MIR4656
Name	microRNA 4656
Location	7p22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4656
Ensembl gene	ENSG00000264474
Ensembl biotype	miRNA
Entrez	100616465
RNAcentral	URS000075DEB1 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579503

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579503 — 1 exons

Exon	Start	End
ENSE00002692286	4788565	4788639

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 69.38.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle layer of sigmoid colon	UBERON:0035805	69.38	gold quality
tibial artery	UBERON:0007610	68.55	gold quality
prostate gland	UBERON:0002367	63.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.55	gold quality
body of uterus	UBERON:0009853	60.71	gold quality
anterior cingulate cortex	UBERON:0009835	59.40	gold quality
substantia nigra	UBERON:0002038	58.94	gold quality
omental fat pad	UBERON:0010414	57.71	gold quality
putamen	UBERON:0001874	57.23	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.75	gold quality
blood	UBERON:0000178	55.16	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	50.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	50.34	gold quality
skin of abdomen	UBERON:0001416	48.45	gold quality
skin of leg	UBERON:0001511	47.44	gold quality
left lobe of thyroid gland	UBERON:0001120	44.99	gold quality
thyroid gland	UBERON:0002046	40.15	silver quality
left testis	UBERON:0004533	37.40	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR4656 is identified as a target of HCP5. Its expression was significantly lower in prostate cancer tissues. miR4656 targets CEMIP in prostate cancer cells. (PMID:31746434)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.