MIR4658

Summary

MIR4658 (microRNA 4658, HGNC:41673) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616439 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41673
Approved symbol	MIR4658
Name	microRNA 4658
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4658
Ensembl gene	ENSG00000284518
Ensembl biotype	miRNA
Entrez	100616439
RNAcentral	URS000075B572 — ncRNA, 65 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584344

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584344 — 1 exons

Exon	Start	End
ENSE00002689670	100156605	100156669

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 88.45.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.45	gold quality
sural nerve	UBERON:0015488	85.55	gold quality
bone marrow	UBERON:0002371	81.78	gold quality
blood	UBERON:0000178	78.77	gold quality
monocyte	CL:0000576	78.35	gold quality
lymph node	UBERON:0000029	77.36	gold quality
rectum	UBERON:0001052	76.71	gold quality
granulocyte	CL:0000094	75.88	gold quality
muscle of leg	UBERON:0001383	74.81	gold quality
calcaneal tendon	UBERON:0003701	74.79	gold quality
gastrocnemius	UBERON:0001388	74.10	gold quality
islet of Langerhans	UBERON:0000006	73.05	gold quality
tonsil	UBERON:0002372	71.63	gold quality
heart left ventricle	UBERON:0002084	71.60	gold quality
heart	UBERON:0000948	70.47	gold quality
Ammon’s horn	UBERON:0001954	70.18	gold quality
body of pancreas	UBERON:0001150	70.17	gold quality
stomach	UBERON:0000945	70.02	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.78	gold quality
body of stomach	UBERON:0001161	69.62	gold quality
right atrium auricular region	UBERON:0006631	69.18	gold quality
tibial artery	UBERON:0007610	68.72	gold quality
liver	UBERON:0002107	68.56	gold quality
right lobe of liver	UBERON:0001114	68.05	gold quality
urinary bladder	UBERON:0001255	67.98	gold quality
fundus of stomach	UBERON:0001160	67.96	gold quality
transverse colon	UBERON:0001157	67.84	gold quality
ascending aorta	UBERON:0001496	67.77	gold quality
thoracic aorta	UBERON:0001515	67.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Variant of SNP rs1317082 at CCSlnc362 (RP11-362K14.5) creates a binding site for miR-4658 and diminishes the susceptibility to colorectal cancer. (PMID:30518759)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.