MIR4659A

Summary

MIR4659A (microRNA 4659a, HGNC:41857) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616348 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41857
Approved symbol	MIR4659A
Name	microRNA 4659a
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4659a
Ensembl gene	ENSG00000266038
Ensembl biotype	miRNA
Entrez	100616348
RNAcentral	URS000075E10B — miRNA, 81 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580269

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580269 — 1 exons

Exon	Start	End
ENSE00002694795	6745164	6745244

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 82.01.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	82.01	gold quality
adrenal tissue	UBERON:0018303	80.20	gold quality
right lobe of liver	UBERON:0001114	79.31	gold quality
placenta	UBERON:0001987	78.06	gold quality
stomach	UBERON:0000945	75.89	gold quality
liver	UBERON:0002107	75.89	gold quality
kidney	UBERON:0002113	75.80	gold quality
monocyte	CL:0000576	75.49	gold quality
urinary bladder	UBERON:0001255	75.44	gold quality
endometrium	UBERON:0001295	75.18	gold quality
blood	UBERON:0000178	74.72	gold quality
sural nerve	UBERON:0015488	74.32	gold quality
gastrocnemius	UBERON:0001388	72.70	gold quality
islet of Langerhans	UBERON:0000006	72.03	gold quality
ectocervix	UBERON:0012249	71.24	gold quality
body of stomach	UBERON:0001161	69.53	gold quality
body of pancreas	UBERON:0001150	69.41	gold quality
adult mammalian kidney	UBERON:0000082	69.30	gold quality
lymph node	UBERON:0000029	69.16	gold quality
right adrenal gland	UBERON:0001233	69.04	gold quality
right lobe of thyroid gland	UBERON:0001119	68.92	gold quality
prefrontal cortex	UBERON:0000451	68.69	gold quality
heart	UBERON:0000948	68.67	gold quality
smooth muscle tissue	UBERON:0001135	68.60	gold quality
amygdala	UBERON:0001876	68.31	gold quality
granulocyte	CL:0000094	67.83	gold quality
lung	UBERON:0002048	67.51	gold quality
saliva-secreting gland	UBERON:0001044	66.91	gold quality
transverse colon	UBERON:0001157	66.89	gold quality
metanephros cortex	UBERON:0010533	66.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.