MIR4659B

Summary

MIR4659B (microRNA 4659b, HGNC:41530) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616372 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41530
Approved symbol	MIR4659B
Name	microRNA 4659b
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4659b
Ensembl gene	ENSG00000283386
Ensembl biotype	miRNA
Entrez	100616372
RNAcentral	URS000075DE1D — miRNA, 73 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636806

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636806 — 1 exons

Exon	Start	End
ENSE00003799687	6745168	6745240

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 71.13.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	71.13	gold quality
caudate nucleus	UBERON:0001873	69.18	gold quality
ascending aorta	UBERON:0001496	67.45	gold quality
Ammon’s horn	UBERON:0001954	66.60	gold quality
transverse colon	UBERON:0001157	66.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.41	gold quality
right atrium auricular region	UBERON:0006631	66.31	gold quality
skin of abdomen	UBERON:0001416	65.75	gold quality
colon	UBERON:0001155	65.66	gold quality
right adrenal gland	UBERON:0001233	65.50	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.71	gold quality
tibial artery	UBERON:0007610	64.33	gold quality
skin of leg	UBERON:0001511	63.02	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.99	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.86	gold quality
thyroid gland	UBERON:0002046	62.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.90	gold quality
esophagus mucosa	UBERON:0002469	61.78	gold quality
tibial nerve	UBERON:0001323	61.76	gold quality
myometrium	UBERON:0001296	60.55	gold quality
right frontal lobe	UBERON:0002810	60.15	gold quality
adenohypophysis	UBERON:0002196	59.81	gold quality
nucleus accumbens	UBERON:0001882	59.59	gold quality
pituitary gland	UBERON:0000007	59.19	gold quality
cerebellar hemisphere	UBERON:0002245	59.19	gold quality
vagina	UBERON:0000996	58.90	gold quality
body of uterus	UBERON:0009853	52.03	gold quality
left testis	UBERON:0004533	40.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.