MIR4660

Summary

MIR4660 (microRNA 4660, HGNC:41861) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616350 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41861
Approved symbol	MIR4660
Name	microRNA 4660
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4660
Ensembl gene	ENSG00000263407
Ensembl biotype	miRNA
Entrez	100616350
RNAcentral	URS000075EFF1 — miRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583549

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583549 — 1 exons

Exon	Start	End
ENSE00002695657	9048445	9048518

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 79.06.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	79.06	gold quality
monocyte	CL:0000576	75.18	gold quality
blood	UBERON:0000178	75.04	gold quality
heart left ventricle	UBERON:0002084	74.14	gold quality
islet of Langerhans	UBERON:0000006	73.06	gold quality
gastrocnemius	UBERON:0001388	72.48	gold quality
hypothalamus	UBERON:0001898	70.42	gold quality
liver	UBERON:0002107	69.68	gold quality
endometrium	UBERON:0001295	68.60	gold quality
body of pancreas	UBERON:0001150	68.51	gold quality
lung	UBERON:0002048	68.24	gold quality
right frontal lobe	UBERON:0002810	68.11	gold quality
left adrenal gland	UBERON:0001234	67.90	gold quality
body of uterus	UBERON:0009853	67.88	gold quality
stomach	UBERON:0000945	67.23	gold quality
upper lobe of left lung	UBERON:0008952	67.14	gold quality
anterior cingulate cortex	UBERON:0009835	66.97	gold quality
left coronary artery	UBERON:0001626	66.71	gold quality
skin of abdomen	UBERON:0001416	66.52	gold quality
substantia nigra	UBERON:0002038	66.34	gold quality
vagina	UBERON:0000996	66.20	gold quality
adult mammalian kidney	UBERON:0000082	65.98	gold quality
ascending aorta	UBERON:0001496	65.96	gold quality
putamen	UBERON:0001874	65.96	gold quality
left ovary	UBERON:0002119	65.85	gold quality
body of stomach	UBERON:0001161	65.63	gold quality
tibial artery	UBERON:0007610	65.34	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.09	gold quality
transverse colon	UBERON:0001157	64.88	gold quality
skin of leg	UBERON:0001511	64.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Expression of the primary hyperoxaluria type 1-causal gene AGXT can be regulated at the posttranscriptional level by miR-4660. (PMID:30852714)
• Role of miR-466 in mesenchymal stromal cell derived extracellular vesicles treating inoculation pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. (PMID:33463070)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.